{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:03:50Z","timestamp":1792602230487,"version":"4.5.0"},"reference-count":32,"publisher":"Canadian Science Publishing","issue":"5","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"crossref","award":["21-14-00226"],"award-info":[{"award-number":["21-14-00226"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"crossref","award":["RSF 21-14-00226"],"award-info":[{"award-number":["RSF 21-14-00226"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:p> Extracellular potassium concentration might modify electrophysiological properties in the border zone of ischemic myocardium. We evaluated the depolarization and repolarization characteristics across the ischemic\u2013normal border under [K<jats:sup>+<\/jats:sup>] variation. Sixty-four-lead epicardial mapping was performed in 26 rats ([K<jats:sup>+<\/jats:sup>] 2.3\u20136.4\u00a0mM) in a model of acute ischemia\/reperfusion. The animals with [K<jats:sup>+<\/jats:sup>] &lt; 4.7\u00a0mM (low\u2013normal potassium) had an ischemic zone with ST-segment elevation and activation delay, a border zone with ST-segment elevation and no activation delay, and a normal zone without electrophysiological abnormalities. The animals with [K<jats:sup>+<\/jats:sup>] &gt;4.7\u00a0mM (normal-high potassium) had only the ischemic and normal zones and no transitional area. Activation\u2013repolarization intervals and local conduction velocities were inversely associated with [K<jats:sup>+<\/jats:sup>] in linear regression analysis with adjustment for the zone of myocardium. The reperfusion extrasystolic burden (ESB) was greater in the low\u2013normal as compared to normal-high potassium animals. Ventricular tachycardia\/fibrillation incidence did not differ between the groups. In patch-clamp experiments, hypoxia shortened action potential duration at 5.4\u00a0mM but not at 1.3\u00a0mM of [K<jats:sup>+<\/jats:sup>]. IK(ATP) current was lower at 1.3\u00a0mM than at 5.4\u00a0mM of [K<jats:sup>+<\/jats:sup>]. We conclude that the border zone formation in low\u2013normal [K<jats:sup>+<\/jats:sup>] was associated with attenuation of IK(ATP) response to hypoxia and increased reperfusion ESB. <\/jats:p>","DOI":"10.1139\/cjpp-2023-0304","type":"journal-article","created":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T21:33:08Z","timestamp":1703107988000},"page":"331-341","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Formation of a border ischemic zone depends on plasma potassium concentration"],"prefix":"10.1139","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9780-1503","authenticated-orcid":false,"given":"Olesya","family":"Bernikova","sequence":"first","affiliation":[{"name":"Department of Cardiac Physiology, Institute of Physiology, Komi Science Center, Ural Branch, Russian Academy of Sciences","place":["Syktyvkar, Russia"]},{"name":"Department of Mathematical Physiology, Institute of 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