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J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:p> Cancer and cardiovascular disease are the leading causes of death for Canadian women. One in eight Canadian women will receive the life-changing diagnosis of breast cancer (BC) in their lifetime, with 1 in 34 dying from the disease. Although doxorubicin (DOX) and trastuzumab (TRZ) have significantly improved survival in women diagnosed with human epidermal growth factor receptor 2 (HER2)-positive BC, approximately one in four women who receive this treatment are at risk of developing chemotherapy-induced cardiotoxicity. Cardiotoxicity is defined as a decline in left ventricular ejection fraction (LVEF) of\u00a0&gt;10% to an absolute value of\u00a0&lt;53%. Current guidelines recommend the serial monitoring of LVEF in this patient population using non-invasive cardiac imaging modalities including transthoracic echocardiography or multi-gated acquisition scan; however, this will only allow for the detection of established cardiotoxicity. Recent studies have demonstrated that a reduction in global longitudinal strain by speckle tracking echocardiography can identify pre-clinical systolic dysfunction prior to a decline in overall LVEF. Implementation of early detection techniques would allow for the prompt initiation of cardioprotective strategies. In addition to the early detection of chemotherapy-mediated cardiotoxicity, the prophylactic use of angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, \u03b2-blockers, statins, exercise, and nutraceutical therapies have been studied in the setting of cardio-oncology. <\/jats:p>","DOI":"10.1139\/cjpp-2023-0358","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T21:33:22Z","timestamp":1701466402000},"page":"487-497","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Preventing broken hearts in women with breast cancer: a concise review on chemotherapy-mediated cardiotoxicity"],"prefix":"10.1139","volume":"102","author":[{"given":"Hilary J.","family":"Bews","sequence":"first","affiliation":[{"name":"Section of Cardiology, Department of Internal Medicine, Rady Faculty of Health Sciences, University of Manitoba","place":["Winnipeg, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lana","family":"Mackic","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences, St. Boniface Hospital, University of Manitoba","place":["Winnipeg, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3639-9047","authenticated-orcid":false,"given":"Davinder S.","family":"Jassal","sequence":"additional","affiliation":[{"name":"Section of Cardiology, Department of Internal Medicine, Rady Faculty of Health Sciences, University of Manitoba","place":["Winnipeg, Canada"]},{"name":"Institute of Cardiovascular Sciences, St. Boniface Hospital, University of Manitoba","place":["Winnipeg, Canada"]},{"name":"Department of Radiology, St. Boniface Hospital, University of Manitoba","place":["Winnipeg, Canada"]},{"name":"Department of Physiology and Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba","place":["Winnipeg, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70042-7"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2022.08.010"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxaa144"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.02.049"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccl.2019.07.005"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2000.2011"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5706561"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-43032-0_15"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.02.072"},{"key":"refg13\/ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32616-2"},{"key":"refg19\/ref19","doi-asserted-by":"publisher","DOI":"10.21147\/j.issn.1000-9604.2016.06.02"},{"key":"refg20\/ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2014.11.020"},{"key":"refg21\/ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2022.104818"},{"key":"refg22\/ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-018-2301-9"},{"key":"refg23\/ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-019-01648-z"},{"key":"refg24\/ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.01.037"},{"key":"refg25\/ref25","doi-asserted-by":"publisher","DOI":"10.1186\/bcr1639"},{"key":"refg26\/ref26","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66544-0"},{"key":"refg27\/ref27","author":"Ellison L.F.","year":"2023","journal-title":"Stat. 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