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J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"<jats:p>Fetal growth restriction is implicated in the programming of later-life neurodegeneration. We hypothesized that growth-restricted offspring would show accelerated changes to microglial white matter morphology, relative to controls. Control guinea pig sows were fed ad libitum, while maternal nutrient restriction sows received 70% of control diet switched to 90% from mid-gestation. Offspring were sacrificed at \u223c26 days (neonate) or \u223c110 days (adult) postpartum. Coronal brain sections from the frontal cortex were subject to IBA1 staining for microglial detection and analyzed by machine learning software. At birth, total body weight of growth-restricted offspring was reduced relative to control ( p\u00a0&lt;\u00a00.0001) with postnatal catch-up growth observed. Microglial density was reduced in the corpus callosum of control ( p\u00a0&lt;\u00a00.05) and growth-restricted ( p\u00a0=\u00a00.13) adults, relative to neonates. Adults from both groups showed greater IBA1-positive area in the cingulum and periventricular white matter ( p\u00a0&lt;\u00a00.05) and increased microglial fractal dimension in the corpus callosum ( p\u00a0&lt;\u00a00.10) and periventricular white matter ( p\u00a0&lt;\u00a00.05), relative to neonates. At the time points studied, we report age-related changes in white matter microglial morphology. 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