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Currently, the treatment of sepsis relies mainly on supportive therapy, and there is a lack of targeted intervention ways. Studying the pathogenesis of sepsis and exploring new therapeutic targets are of great theoretical and clinical importance. Calcium-sensitive receptor (CaSR) is a cell membrane receptor belonging to the family of G protein-coupled receptors and is widely distributed in various tissues and organs. Research indicates that CaSR plays a role in mitigating sepsis-induced organ dysfunction, exhibiting tissue-specific protective effects in certain tissues while inducing inflammatory responses in others. Elucidating these dual effects and the underlying signaling pathways could facilitate the development of targeted therapies for sepsis-related organ damage. This review summarizes recent literature and evidence on CaSR signaling in sepsis-induced organ dysfunction. In addition, we provide an up-to-date schematic of the most important and likely molecular signaling pathways associated with CaSR in sepsis. <\/jats:p>","DOI":"10.1139\/cjpp-2025-0004","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T21:35:25Z","timestamp":1746048925000},"page":"286-297","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["The calcium-sensitive receptor in the pathogenesis of sepsis"],"prefix":"10.1139","volume":"103","author":[{"given":"Bin","family":"Yu","sequence":"first","affiliation":[{"name":"Guangyuan Central Hospital, Affiliated Hospital of North Sichuan Medical College","place":["Guangyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelian","family":"Li","sequence":"additional","affiliation":[{"name":"Jiangyou People's Hospitol","place":["Jia ngyou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"Guangyuan Central Hospital, Affiliated Hospital of North Sichuan Medical College","place":["Guangyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Han","sequence":"additional","affiliation":[{"name":"Guangyuan Central Hospital, Affiliated Hospital of North Sichuan Medical College","place":["Guangyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Tan","sequence":"additional","affiliation":[{"name":"Guangyuan Central Hospital, Affiliated Hospital of North Sichuan Medical College","place":["Guangyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Yu","sequence":"additional","affiliation":[{"name":"Guangyuan Central Hospital, Affiliated Hospital of North Sichuan Medical College","place":["Guangyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[{"name":"Guangyuan Central Hospital, Affiliated Hospital of North Sichuan Medical College","place":["Guangyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Xu","sequence":"additional","affiliation":[{"name":"Guangyuan Central Hospital, Affiliated Hospital of North Sichuan Medical College","place":["Guangyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5689-9825","authenticated-orcid":false,"given":"Xiongying","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangyuan Central Hospital, Affiliated Hospital of North Sichuan Medical College","place":["Guangyuan, China"]},{"name":"Department of Pediatric Intensive Care Unit Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.113.205534"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01042.2007"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.05.028"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181bfe856"},{"key":"refg5\/ref5","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1055\/a-0625-5492","volume":"54","author":"Bracht H.","year":"2019","journal-title":"Anasthesiol. 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