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J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:p>\n                    Ionizing radiation is a known risk factor for the occurrence and development of cardiovascular diseases, particularly in patients receiving thoracic radiotherapy. This exposure leads to oxidative stress and inflammation, which can damage cardiac tissue and vascular endothelium. Molecular hydrogen (H\n                    <jats:sub>2<\/jats:sub>\n                    ) has been recognized for its therapeutic potential, including antioxidant effects. In this study, male Wistar rats were irradiated with a dose of 10\u00a0Gy (X-rays) in the chest area. Two and 9 days post-irradiation, significant increases in lactate dehydrogenase (LDH), catalase, glutathione peroxidase activity, malondialdehyde, superoxide, and tumor necrosis factor alpha levels were observed in the rat blood plasma or heart tissue. Administration of H\n                    <jats:sub>2<\/jats:sub>\n                    either via drinking H\n                    <jats:sub>2<\/jats:sub>\n                    -rich water (min. 4\u00a0mg\/L) or inhaling H\n                    <jats:sub>2<\/jats:sub>\n                    in air (4%), effectively decreased oxidative stress, LDH, and inflammatory proteins to normal levels. H\n                    <jats:sub>2<\/jats:sub>\n                    also normalized the nuclear factor erythroid 2-related factor 2\/Kelch-like ECH-associating protein 1 (Nrf2\/Keap1) pathway, an important antioxidative response regulator activated by irradiation. Based on these results, we can conclude that H\n                    <jats:sub>2<\/jats:sub>\n                    administration through both routes mitigated heart damage caused by irradiation after 2 and 9 days. The mitigating effect exerted more pronounced trend with H\n                    <jats:sub>2<\/jats:sub>\n                    gas inhalation, but further research is needed for statistically relevant data and mechanistic insights.\n                  <\/jats:p>","DOI":"10.1139\/cjpp-2025-0085","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T21:34:33Z","timestamp":1773178473000},"page":"1-13","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of hydrogen administration methods in the treatment of radiation-induced heart disease in rats"],"prefix":"10.1139","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6743-491X","authenticated-orcid":false,"given":"Branislav","family":"Kura","sequence":"first","affiliation":[{"name":"Slovak Academy of Sciences","place":["Bratislava, 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