{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T11:39:58Z","timestamp":1793187598543,"version":"4.5.0"},"reference-count":21,"publisher":"Canadian Science Publishing","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:p>Acute cervical spinal cord injury (cSCI) disrupts supraspinal autonomic cardiovascular control. Heart rate variability (HRV), assessed using linear and nonlinear methods, provides a sensitive index of cardiovascular autonomic regulation. To evaluate linear and nonlinear HRV parameters associated with autonomic cardiovascular dysregulation in acute cSCI. This monocentric prospective study included 500 patients with traumatic or non-traumatic acute cSCI and 200 age- and sex-matched healthy controls. All participants underwent 24 h Holter ECG monitoring. Time- and frequency-domain indices and nonlinear metrics, including Poincar\u00e9 plot analysis, entropy, detrended fluctuation analysis, and recurrence quantification analysis, were calculated. Predictive modeling used logistic regression, random forest, gradient boosting, and support vector machine algorithms with cross-validation. Both cSCI groups showed significantly reduced HRV amplitude and altered autonomic cardiovascular regulation. Nonlinear indices demonstrated reduced entropy, altered fractal scaling, and decreased recurrence dynamics. Female patients showed relatively preserved nonlinear HRV parameters. Models combining linear and nonlinear features discriminated autonomic dysfunction better than models using conventional HRV metrics alone. Combined linear and nonlinear HRV analysis provides complementary characterization of autonomic cardiovascular dysregulation following acute cSCI.<\/jats:p>","DOI":"10.1139\/cjpp-2026-0083","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:34:06Z","timestamp":1790804046000},"page":"1-12","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Autonomic cardiovascular dysregulation after acute cervical spinal cord injury: insights from linear and nonlinear heart rate variability"],"prefix":"10.1139","volume":"104","author":[{"given":"Antonija","family":"Krsta\u010di\u0107","sequence":"first","affiliation":[{"name":"Josip Juraj Strossmayer University of Osijek","place":["Osijek, Croatia"]},{"name":"University Hospital Centre Sisters of Mercy","place":["Zagreb, Croatia"]},{"name":"University of Applied Health Sciences","place":["Zagreb, Croatia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0427-7229","authenticated-orcid":false,"given":"Goran","family":"Krsta\u010di\u0107","sequence":"additional","affiliation":[{"name":"Josip Juraj Strossmayer University of Osijek","place":["Osijek, Croatia"]},{"name":"University of Applied Health Sciences","place":["Zagreb, Croatia"]},{"name":"Institute for Cardiovascular Prevention and Rehabilitation","place":["Zagreb, Croatia"]},{"name":"International Academy of Sciences and Arts in Bosnia and Herzegovina","place":["Sarajevo, Bosnia and Herzegovina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0071-8376","authenticated-orcid":false,"given":"Vladimir","family":"Jakovljevi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences University of Kragujevac","place":["Kragujevac, Serbia"]},{"name":"Faculty of Medical Sciences University of Kragujevac","place":["Kragujevac, Serbia"]},{"name":"I.M. 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