{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:33:58Z","timestamp":1790130838146,"version":"4.0.1"},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"9","license":[{"start":{"date-parts":[[1998,9,1]],"date-time":"1998-09-01T00:00:00Z","timestamp":904608000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1998,9,1]]},"abstract":"<jats:p> The influence of cold exposure on immune function is reviewed. Data obtained mainly on small mammals suggest that the acute effect of severe chilling is a suppression of several cellular and humoral components of the immune response, including a decrease of lymphocyte proliferation, a down-regulation of the immune cascade, a reduction of natural killer (NK) cell count, cytolytic activity, activation of complement, and the induction of heat shock proteins. However, adaptation to a given cold stimulus appears to develop over the course of 2-3 weeks. Further work is needed to examine interactions between cold exposure and exercise, and to determine whether the disturbances of immune response are sufficient to impair immunosurveillance in human subjects.Key words: cytolic activity, heat shock proteins, hypothermia, infection, leukocytes. <\/jats:p>","DOI":"10.1139\/y98-097","type":"journal-article","created":{"date-parts":[[2011,4,23]],"date-time":"2011-04-23T17:05:30Z","timestamp":1303578330000},"page":"828-836","source":"Crossref","is-referenced-by-count":104,"title":["Cold exposure and immune function"],"prefix":"10.1139","volume":"76","author":[{"given":"Roy J","family":"Shephard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pang N","family":"Shek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y98-097","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T10:29:35Z","timestamp":1578220175000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y98-097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,9,1]]},"references-count":0,"aliases":["10.1139\/cjpp-76-9-828"],"journal-issue":{"issue":"9","published-print":{"date-parts":[[1998,9,1]]}},"alternative-id":["10.1139\/y98-097"],"URL":"https:\/\/doi.org\/10.1139\/y98-097","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,9,1]]}}}