{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T02:54:33Z","timestamp":1649213673753},"reference-count":4,"publisher":"Canadian Science Publishing","issue":"2","license":[{"start":{"date-parts":[[1972,6,1]],"date-time":"1972-06-01T00:00:00Z","timestamp":76204800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Genet. Cytol."],"published-print":{"date-parts":[[1972,6,1]]},"abstract":"<jats:p> Both the KK and the A<jats:sup>y<\/jats:sup> mouse exhibit many symptoms of diabetes. Glucosuria is the most satisfactory test for this condition in mice. Glucosuria is inherited as a dominant in both strains, but many factors reduce its penetrance. The penetrance in the KK strain can be increased from 23 to 62% by crossing to C57BL\/10J and then selecting the most effective background modifiers. The number of modifiers must be small because response was rapid and fixation fast. The cross KK\u2002\u00d7\u2002A<jats:sup>y<\/jats:sup> gives yellow and black offspring in equal numbers. The yellows have the dominant genes for glucosuria from both strains, and the males all become glucosuric by the time they are 8 months old, in comparison to 7% of the males in the parental yellow strain. Of the yellow females, 88% are glucosuric by 1 year in comparion to 0% of the yellow strain or 2% of the KK's. The black males which lack the gene from the A<jats:sup>y<\/jats:sup> strain but do have the gene from the KK have no glucosurics at 8 months and only 2% at 1 year. The F<jats:sub>1<\/jats:sub> of the cross KK\u2002\u00d7\u2002A<jats:sup>y<\/jats:sup> provides valuable research material since all yellow males will become glucosuric by 8 months of age and none of their black litter mates will. <\/jats:p>","DOI":"10.1139\/g72-033","type":"journal-article","created":{"date-parts":[[2014,11,28]],"date-time":"2014-11-28T15:37:54Z","timestamp":1417189074000},"page":"265-269","source":"Crossref","is-referenced-by-count":6,"title":["THE INHERITANCE OF GLUCOSURIA IN THE KK AND A<sup>y<\/sup> MOUSE"],"prefix":"10.1139","volume":"14","author":[{"given":"L.","family":"Butler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"p_1\/p_1_1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/BF01212224","volume":"6","author":"Butler L.","year":"1970","journal-title":"Diabetologia"},{"key":"p_2\/p_2_1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1152\/ajplegacy.1958.193.3.499","volume":"193","author":"Carpenter K. J.","year":"1958","journal-title":"Am. J. Physiol."},{"key":"p_3\/p_3_1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/BF01212245","volume":"6","author":"Dulin W. E.","year":"1970","journal-title":"Diabetologia"},{"key":"p_5\/p_5_1","doi-asserted-by":"crossref","first-page":"348","DOI":"10.2183\/pjab1945.38.348","volume":"38","author":"Nakamura M.","year":"1962","journal-title":"Proc. Japan. Acad."}],"container-title":["Canadian Journal of Genetics and Cytology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/g72-033","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T15:44:01Z","timestamp":1578239041000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/g72-033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,6,1]]},"references-count":4,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1972,6,1]]}},"alternative-id":["10.1139\/g72-033"],"URL":"https:\/\/doi.org\/10.1139\/g72-033","relation":{},"ISSN":["0008-4093"],"issn-type":[{"value":"0008-4093","type":"print"}],"subject":[],"published":{"date-parts":[[1972,6,1]]}}}