{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T19:05:06Z","timestamp":1748977506776},"reference-count":2,"publisher":"Canadian Science Publishing","issue":"4","license":[{"start":{"date-parts":[[1972,12,1]],"date-time":"1972-12-01T00:00:00Z","timestamp":92016000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Genet. Cytol."],"published-print":{"date-parts":[[1972,12,1]]},"abstract":"<jats:p> A method is described for determining which diseases cluster more frequently in families as indicated by data drawn from a large population of linked family records. First, a screening test determined which diseases were distributed differently in sibs than in the general population using a chi-squared test. Fisher's exact test was used for two subsequent analyses to handle the small expected values for affected sibs. One analysis identified index diseases which occurred more frequently than expected in the sibs of index cases and the other test identified which diseases other than those of the index case were actually associated with index diseases.The methods were tested-using data from a \"Registry for Handicapped Children and Adults\" and the vital registrations for the Canadian province of British Columbia, which had been linked by computer into family groups by Newcombe. The index disease occurred more frequently than expected in sibs for erythroblastosis, strabismus, immaturity, post-natal asphyxia and atelectasis and mental deficiency. Familial associations which had not been previously reported were: erythroblastosis with diseases of the digestive system, strabismus with diseases of the nervous system and sense organs, immaturity with both diseases of early infancy and stillbirths, post-natal asphyxia and atelectasis with stillbirths, congenital malformations of the digestive system with other congenital malformations and mental deficiency with diseases of the respiratory system.The shortcomings of the data are discussed, and instances in which the results are not conclusive, or are not readily interpretable, but are indicative of possible interesting problems in need of investigation, are noted. <\/jats:p>","DOI":"10.1139\/g72-097","type":"journal-article","created":{"date-parts":[[2014,11,28]],"date-time":"2014-11-28T20:38:52Z","timestamp":1417207132000},"page":"789-800","source":"Crossref","is-referenced-by-count":2,"title":["ASSOCIATION OF CHILDREN'S DISEASES IN FAMILIES FROM RECORD LINKAGE DATA"],"prefix":"10.1139","volume":"14","author":[{"given":"Nancy E.","family":"Simpson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. Jane","family":"Alleslev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"p_1\/p_1_1","author":"Carter C. O.","journal-title":"J. Biosoc.Sci' l: 71-83."},{"key":"p_6\/p_6_1","author":"Newcombe B","journal-title":"Brit. J. Prev. Soc. Med.2O: 49-57."}],"container-title":["Canadian Journal of Genetics and Cytology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/g72-097","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T20:43:54Z","timestamp":1578257034000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/g72-097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,12,1]]},"references-count":2,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1972,12,1]]}},"alternative-id":["10.1139\/g72-097"],"URL":"https:\/\/doi.org\/10.1139\/g72-097","relation":{},"ISSN":["0008-4093"],"issn-type":[{"value":"0008-4093","type":"print"}],"subject":[],"published":{"date-parts":[[1972,12,1]]}}}