{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T18:04:36Z","timestamp":1699985076427},"reference-count":16,"publisher":"Canadian Science Publishing","issue":"1","license":[{"start":{"date-parts":[[1978,3,1]],"date-time":"1978-03-01T00:00:00Z","timestamp":257558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Genet. Cytol."],"published-print":{"date-parts":[[1978,3,1]]},"abstract":"<jats:p> Exposure of cultured human fibroblasts to hyperthermia delayed the host-cell reactivation of UV-irradiated human adenovirus type 12 (AD12). The experimental design consisted of irradiating human AD12 with UV doses ranging from 180 to 1800\u2002ergs\/mm<jats:sup>2<\/jats:sup>, infecting human cell populations at 37 \u00b0C, exposing the infected cells for 7\u2002h to 39.5 \u00b0C and 41.8 \u00b0C, returning them to 37 \u00b0C and estimating the frequency of cells with intranuclear viral inclusion bodies (IB) 41 and 89\u2002h after hyperthermia treatment. Hyperthermia reduced the fractions of fibroblasts with viral IB in the 41\u2002h samples. By 89\u2002h the capacity to form IB in the treated cells was comparable to that in control cells. Hyperthermia of 39.5 and 41.8 \u00b0C for 7\u2002h did not affect the replication of nonirradiated AD12. The pattern of host-cell reactivation of AD12 following hyperthermia was compared to that in DNA repair deficient xeroderma pigmentosum cell populations. <\/jats:p>","DOI":"10.1139\/g78-006","type":"journal-article","created":{"date-parts":[[2014,11,28]],"date-time":"2014-11-28T20:25:44Z","timestamp":1417206344000},"page":"35-40","source":"Crossref","is-referenced-by-count":4,"title":["HYPERTHERMIA AND HOST-CELL REACTIVATION OF ADENOVIRUS 12"],"prefix":"10.1139","volume":"20","author":[{"given":"P.","family":"Lam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. F.","family":"Stich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"p_2\/p_2_1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/B978-0-12-035406-1.50012-9","volume":"6","author":"Bronk B. V.","year":"1976","journal-title":"Adv. Radiat. 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