{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:42:18Z","timestamp":1790739738419,"version":"4.1.0"},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"2","license":[{"start":{"date-parts":[[1989,1,15]],"date-time":"1989-01-15T00:00:00Z","timestamp":600825600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genome"],"published-print":{"date-parts":[[1989,1,15]]},"abstract":"<jats:p> Human T-cell leukemia virus type 1 (HTLV-1) has two trans-acting regulator genes, tax and rex, in the pX region. The tax gene is a trans-acting transcriptional activator of the long terminal repeat (LTR) and also of the cellular gene for IL-2R\u03b1. The latter seems to explain initiation of abnormal growth of HTLV-1 infected cells. The rex gene is a posttranscriptional regulator accumulating gag and env mRNA and also indirectly suppressing the transcription. The regulation requires two cis-acting elements, the LTR sequence at the 3\u2032 terminus and 5\u2032 splice signal, suggesting a novel mechanism of RNA processing in the nucleus. These two trans-activator genes are essential for efficient replication of HTLV-1 and also explain its poor replication competence and tendency to be latent in vivo.Key words: HTLV-1, trans-activation, posttranscriptional regulation, RNA splicing. <\/jats:p>","DOI":"10.1139\/g89-121","type":"journal-article","created":{"date-parts":[[2011,4,24]],"date-time":"2011-04-24T09:33:05Z","timestamp":1303637585000},"page":"662-667","source":"Crossref","is-referenced-by-count":23,"title":["Molecular mechanisms of regulation of HTLV-1 gene expression and its association with leukemogenesis"],"prefix":"10.1139","volume":"31","author":[{"given":"Mitsuaki","family":"Yoshida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichiro","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Fujisawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoharu","family":"Seiki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","container-title":["Genome"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/g89-121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T14:13:16Z","timestamp":1578233596000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/g89-121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,1,15]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1989,1,15]]}},"alternative-id":["10.1139\/g89-121"],"URL":"https:\/\/doi.org\/10.1139\/g89-121","relation":{},"ISSN":["0831-2796","1480-3321"],"issn-type":[{"value":"0831-2796","type":"print"},{"value":"1480-3321","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,1,15]]}}}