{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T08:42:11Z","timestamp":1781944931445,"version":"3.54.5"},"reference-count":113,"publisher":"Canadian Science Publishing","issue":"4","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Genome"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p> Hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) is a natural toxicant in some aquatic environments that has diverse molecular targets. It binds to oxygen transport proteins, rendering them non-functional by reducing oxygen-binding affinity. Hence, organisms permanently inhabiting H<jats:sub>2<\/jats:sub>S-rich environments are predicted to exhibit adaptive modifications to compensate for the reduced capacity to transport oxygen. We investigated 10 lineages of fish of the family Poeciliidae that have colonized freshwater springs rich in H<jats:sub>2<\/jats:sub>S\u2014along with related lineages from non-sulfidic environments\u2014to test hypotheses about the expression and evolution of oxygen transport genes in a phylogenetic context. We predicted shifts in the expression of and signatures of positive selection on oxygen transport genes upon colonization of H<jats:sub>2<\/jats:sub>S-rich habitats. Our analyses indicated significant shifts in gene expression for multiple hemoglobin genes in lineages that have colonized H<jats:sub>2<\/jats:sub>S-rich environments, and three hemoglobin genes exhibited relaxed selection in sulfidic compared to non-sulfidic lineages. However, neither changes in gene expression nor signatures of selection were consistent among all lineages in H<jats:sub>2<\/jats:sub>S-rich environments. Oxygen transport genes may consequently be predictable targets of selection during adaptation to sulfidic environments, but changes in gene expression and molecular evolution of oxygen transport genes in H<jats:sub>2<\/jats:sub>S-rich environments are not necessarily repeatable across replicated lineages. <\/jats:p>","DOI":"10.1139\/gen-2017-0051","type":"journal-article","created":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T17:33:39Z","timestamp":1513013619000},"page":"273-286","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["Molecular evolution and expression of oxygen transport genes in livebearing fishes (Poeciliidae) from hydrogen sulfide rich springs"],"prefix":"10.1139","volume":"61","author":[{"given":"Nicholas","family":"Barts","sequence":"first","affiliation":[{"name":"Division of Biology, Kansas State University, 116 Ackert Hall, Manhattan, KS 66506, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Greenway","sequence":"additional","affiliation":[{"name":"Division of Biology, Kansas State University, 116 Ackert Hall, Manhattan, KS 66506, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney N.","family":"Passow","sequence":"additional","affiliation":[{"name":"Ecology, Evolution and Behavior, University of Minnesota St. Paul, 205 Cargill Building, St. Paul, MN 55108, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenin","family":"Arias-Rodriguez","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n Acad\u00e9mica de Ciencias Biol\u00f3gicas, Universidad Ju\u00e1rez Aut\u00f3noma de Tabasco (UJAT), C.P. 86150, Villahermosa, Tabasco, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna L.","family":"Kelley","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Washington State University, 431 Heald Hall, Pullman, WA 99164, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Tobler","sequence":"additional","affiliation":[{"name":"Division of Biology, Kansas State University, 116 Ackert Hall, Manhattan, KS 66506, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0403929101"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","unstructured":"Auwera, G.A., Carneiro, M.O., Hartl, C., Poplin, R., del Angel, G., Levy-Moonshine, A., et al. 2013. 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