{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:09:39Z","timestamp":1793120979017,"version":"4.5.0"},"reference-count":24,"publisher":"Canadian Science Publishing","issue":"4","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Genome"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p> Treatment scale-up is leading to a progressive increase in HIV resistance to antiretrovirals, especially in children. To assess resistance to reverse transcriptase inhibitors (RTIs) in HIV-1 infected children in C\u00f4te d\u2019Ivoire, genotypic resistance tests were performed and interpreted using the ANRS algorithm ( www.hivfrenchresistance.org ). Phylogenetic trees were created using BioEdit v7 and Mega7 software. The frequency of resistance to at least one RTI was 79%. It was 88% for nucleoside reverse transcriptase inhibitors (NRTIs), 71% for non-nucleoside reverse transcriptase inhibitors (NNRTIs), and 63% for both classes (NRTI + NNRTI). The frequency of resistance was 50% for the ZDV + 3TC + EFV combination, 42% for the ABC + 3TC + EFV combination, and 8% for the TDF + 3TC + EFV combination. Frequently encountered resistance mutations were for NRTIs: M184V (88%), TAMs (67%), T215F\/I\/V\/Y (33%), and L74I\/V (24%); for NNRTIs: K103N\/S (74%), P225H (26%), and G190A\/E\/Q (24%). The synthesis of phylogenetic analyses showed the predominance of the viral subtype CRF02_AG (85%). These results show a high prevalence of resistance to RTIs in children infected with HIV-1. Hence the interest of a more accessible monitoring of viral load and genotypic resistance tests in HIV-1 infected children undergoing treatment in C\u00f4te d\u2019Ivoire. <\/jats:p>","DOI":"10.1139\/gen-2020-0112","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T21:39:06Z","timestamp":1605044346000},"page":"347-354","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Determination of reverse transcriptase inhibitor resistance mutations in HIV-1 infected children in C\u00f4te d\u2019Ivoire"],"prefix":"10.1139","volume":"64","author":[{"given":"Massara","family":"Camara-Cisse","sequence":"first","affiliation":[{"name":"Laboratory of Biochemistry, UFR Medical Sciences, University F\u00e9lix Houphou\u00ebt-Boigny (UFHB), BP 582 Abidjan 22-C\u00f4te d\u2019Ivoire."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youzan 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