{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T04:10:01Z","timestamp":1751515801973,"version":"3.41.0"},"reference-count":53,"publisher":"Canadian Science Publishing","issue":"11","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.en_GB"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Genome"],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:p> Half-chromatid mutations occur when a single base change in a gamete is transmitted to the zygote, which, after DNA replication and cleavage, will result in a mosaic individual. These mutations will be passed on through the germ plasm and also may be expressed somatically. Half-chromatid mutation has been suggested to account for the observed lower frequency of males than expected for lethal X-linked recessive disorders in humans, such as Lesch\u2013Nyhan syndrome, incontinentia pigmenti, and Duchene muscular dystrophy. Although attention has been paid to half-chromatid mutation in humans, it otherwise has been ignored. Here I show that half-chromatid mutation in haplodiploid organisms, such as Hymenoptera, has some interesting and important consequences: ( i) since all genes follow the X-linked pattern of inheritance, half-chromatid mutations should be relatively easier to detect; ( ii) recessive mutations of all viabilities may be expected; ( iii) mosaics of both sexes are expected in haplodiploids with half-chromatid mutation; ( iv) gynandromorphs could result from half-chromatid mutation at the sex-determination locus, in species with single-locus complementary sex-determination. Finally, half-chromatid mutation can account for the rare fertile male tortoiseshell phenotype observed in the domestic cat, Felis catus, and which still has not been fully accounted for by other mechanisms. <\/jats:p>","DOI":"10.1139\/gen-2023-0006","type":"journal-article","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T21:36:33Z","timestamp":1686605793000},"page":"295-304","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Half-chromatid mutation as a possible cause of mosaic males and females in Hymenoptera and rare fertile male tortoiseshell cats"],"prefix":"10.1139","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1508-6308","authenticated-orcid":false,"given":"Robin E.","family":"Owen","sequence":"first","affiliation":[{"name":"Mount Royal University","place":["Calgary, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1093\/genetics\/86.3.583","volume":"86","author":"Adams J.","year":"1977","journal-title":"Genetics"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.108.095018"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1007\/BF02991448"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2006.12.015"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jhered.a108410"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.107.078980"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1038\/hdy.1993.157"},{"key":"refg8\/ref8","unstructured":"Crozier R.H. 1975. 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