{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T03:18:47Z","timestamp":1782443927744,"version":"3.54.5"},"reference-count":54,"publisher":"Canadian Science Publishing","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"funder":[{"DOI":"10.13039\/501100001503","name":"Indian Council of Agricultural Research","doi-asserted-by":"crossref","award":["IXX12176"],"award-info":[{"award-number":["IXX12176"]}],"id":[{"id":"10.13039\/501100001503","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Genome"],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:p> Pasteurella multocida causes acute\/chronic pasteurellosis in porcine, resulting in considerable economic losses globally. The draft genomes of two Indian strains NIVEDIPm17 (serogroup D) and NIVEDIPm36 (serogroup A) were sequenced. A total of 2182\u20132284 coding sequences (CDSs) were predicted along with 5\u20136 rRNA and 45\u201346 tRNA genes in the genomes. Multilocus sequence analysis and LPS genotyping showed the presence of ST50: genotype 07 and ST74: genotype 06 in NIVEDIPm17 and NIVEDIPm36, respectively. Pangenome analysis of 61 strains showed the presence of 1653 core genes, 167 soft core genes, 750 shell genes, and 1820 cloud genes. Analysis of virulence-associated genes in 61 genomes indicated the presence of nanB, exbB, exbD, ptfA, ompA, ompH, fur, plpB, fimA, sodA, sodC, tonB, and omp87 in all strains. The 61 genomes contained genes encoding tetracycline (54%), streptomycin (48%), sulphonamide (28%), tigecycline (25%), chloramphenicol (21%), amikacin (7%), cephalosporin (5%), and trimethoprim (5%) resistance. Multilocus sequence type revealed that ST50 was the most common (34%), followed by ST74 (26%), ST13 (24%), ST287 (5%), ST09 (5%), ST122 (3%), and ST07 (2%). Single-nucleotide polymorphism and core genome-based phylogenetic analysis clustered the strains into three major clusters. In conclusion, we described the various virulence factors, mobile genetic elements, and antimicrobial resistance genes in the pangenome of P. multocida of porcine origin, besides the rare presence of LPS genotype 7 in serogroup D. <\/jats:p>","DOI":"10.1139\/gen-2023-0021","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T21:40:40Z","timestamp":1693258840000},"page":"13-23","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparative genome analysis of <i>Pasteurella multocida<\/i> strains of porcine origin"],"prefix":"10.1139","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3876-1468","authenticated-orcid":false,"given":"Awadhesh","family":"Prajapati","sequence":"first","affiliation":[{"name":"ICAR \u2013 National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI)","place":["Bengaluru, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1980-7034","authenticated-orcid":false,"given":"Revanaiah","family":"Yogisharadhya","sequence":"additional","affiliation":[{"name":"ICAR \u2013 National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI)","place":["Bengaluru, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0397-579X","authenticated-orcid":false,"given":"Nihar Nalini","family":"Mohanty","sequence":"additional","affiliation":[{"name":"CCS \u2013 National Institute of Animal Health (NIAH)","place":["Baghpat, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh Kumar","family":"Mendem","sequence":"additional","affiliation":[{"name":"ICAR \u2013 National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI)","place":["Bengaluru, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5727-8658","authenticated-orcid":false,"given":"Mohammed Mudassar","family":"Chanda","sequence":"additional","affiliation":[{"name":"ICAR \u2013 National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI)","place":["Bengaluru, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivakumara","family":"Siddaramappa","sequence":"additional","affiliation":[{"name":"Institute of Bioinformatics and Applied Biotechnology (IBAB)","place":["Bengaluru, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3575-5564","authenticated-orcid":false,"given":"Sathish Bhadravati","family":"Shivachandra","sequence":"additional","affiliation":[{"name":"ICAR \u2013 National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI)","place":["Bengaluru, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-016-3407-6"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-12-402"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1038\/75556"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz423"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-9-75"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.063461-0"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.00961"},{"key":"refg9\/ref9","first-page":"481","volume":"16","author":"Carter G.R.","year":"1955","journal-title":"Am. 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