{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T04:55:17Z","timestamp":1697518517937},"reference-count":30,"publisher":"Canadian Science Publishing","issue":"6","license":[{"start":{"date-parts":[[2003,12,1]],"date-time":"2003-12-01T00:00:00Z","timestamp":1070236800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Appl. Physiol."],"published-print":{"date-parts":[[2003,12,1]]},"abstract":"<jats:p> There is evidence that the slope of the change in oxygen uptake accompanying changes in work rate ([Formula: see text]) during moderate incremental exercise is influenced by fitness (peak[Formula: see text]). We set out to determine whether [Formula: see text] was related to fitness in a group of healthy children and in children with juvenile dermatomyositis (JDM), a condition associated with decreased peak [Formula: see text]. We also hypothesized that [Formula: see text] would be significantly decreased in children with JDM compared to healthy children. Methods: Twelve children (2 boys) with JDM, mean age 11.6\u2002\u00b1\u20023.6\u2002yrs, and 20 healthy children (4 boys), mean age 11.3\u2002\u00b1\u20022.9 years, performed an incremental exercise test using a cycle ergometer. [Formula: see text] below the anaerobic threshold was analyzed using linear regression. Correlations between peak [Formula: see text] and [Formula: see text] were calculated, and differences between the JDM and healthy groups were analyzed using independent t-tests. Results: The [Formula: see text] was significantly correlated with peak[Formula: see text] for children with JDM (r\u2002=\u20020.71,p\u2002&lt;\u20020.01), healthy children (r\u2002=\u20020.53, p\u2002&lt;\u20020.01), and all children combined (r\u2002=\u20020.78, p\u2002&lt;\u20020.001). The [Formula: see text] (7.4\u2002\u00b1\u20021.4 vs. 10.8\u2002\u00b1\u20021.2\u2002ml O<jats:sub>\u2022<\/jats:sub>min<jats:sup>\u22121<\/jats:sup>\u2022wat<jats:sup>\u22121<\/jats:sup>) and peak oxygen uptake ([Formula: see text]) (19.2\u2002\u00b1\u20025.0 vs. 31.4\u2002\u00b1\u20027.2\u2002ml O<jats:sub>2<\/jats:sub>\u2022kg<jats:sup>\u22121<\/jats:sup>\u2022min<jats:sup>\u22121<\/jats:sup>) were significantly lower in children with JDM than in healthy children, respectively (all p\u2002\u2264\u20020.001). Conclusion: Fitness is significantly related to [Formula: see text] in healthy children and those with JDM. Children with JDM have a significantly lower [Formula: see text] than healthy children. Further study is needed to identify specific factors influencing [Formula: see text]. Key words: exercise efficiency, juvenile dermatomyositis, peak [Formula: see text] <\/jats:p>","DOI":"10.1139\/h03-063","type":"journal-article","created":{"date-parts":[[2009,6,3]],"date-time":"2009-06-03T17:12:10Z","timestamp":1244049130000},"page":"888-897","source":"Crossref","is-referenced-by-count":18,"title":["Fitness as a Determinant of the Oxygen Uptake\/Work Rate Slope in Healthy Children and Children With Inflammatory Myopathy"],"prefix":"10.1139","volume":"28","author":[{"given":"Bart E.","family":"Drinkard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne","family":"Hicks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerome","family":"Danoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa G.","family":"Rider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"p_1\/p_1_1","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0733-8619(05)70337-6","volume":"15","author":"Amato A.","year":"1997","journal-title":"Neurol. 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