{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T23:10:39Z","timestamp":1707174639278},"reference-count":29,"publisher":"Canadian Science Publishing","issue":"4","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Appl. Physiol. Nutr. Metab."],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:p>Modulation of \u03b2-adrenergic receptor (\u03b2-AR) activity affects muscle mass and could have a role in the reduction of muscle mass observed following spinal cord transection (Tx). The aims of this study were to examine the early acute effects of Tx on muscle mass, total and myofibrillar protein concentrations, cytochrome c oxidase activity, and \u03b2-AR density of skeletal muscle, to ascertain if any change in muscle properties could be related to \u03b2-AR signalling events. Female Sprague\u2013Dawley rats (n = 33; ~255\u00a0g) were randomly assigned to 4 experimental groups: control 4\u00a0d, control 8\u00a0d, Tx 4\u00a0d, and Tx 8\u00a0d. A complete Tx was performed surgically at the T10 cord level. Compared with controls, muscle mass and muscle \u2013 body mass ratios decreased significantly following Tx, with no significant change observed in total and myofibrillar protein concentrations. Spinal cord Tx also resulted in a significant decrease in plantaris cytochrome c oxidase activity by 24% at Tx 4 d and 28% at Tx 8 d (p &lt; 0.05). \u03b2-AR density of the lateral gastrocnemius was unchanged; however, the \u03b2-AR density of the forelimb triceps brachii m. was found to increase after Tx. Our results suggest that changes in muscle mass and cytochrome c oxidase activity rapidly occur after Tx and do not appear to be related to changes in \u03b2-AR density.<\/jats:p>","DOI":"10.1139\/h06-016","type":"journal-article","created":{"date-parts":[[2006,8,9]],"date-time":"2006-08-09T16:09:59Z","timestamp":1155139799000},"page":"398-406","source":"Crossref","is-referenced-by-count":2,"title":["Early effects of spinal cord transection on skeletal muscle properties"],"prefix":"10.1139","volume":"31","author":[{"given":"Melissa D.","family":"Kelley","sequence":"first","affiliation":[{"name":"Department of Biology, Acadia University, Wolfville, NS B4P 2R6, Canada."},{"name":"D\u00e9partement de Pharmacologie, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC H3C 3J7, Canada."},{"name":"School of Recreation Management and Kinesiology, Acadia University, Wolfville, NS B4P 2R6, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satra","family":"Nim","sequence":"additional","affiliation":[{"name":"Department of Biology, Acadia University, Wolfville, NS B4P 2R6, Canada."},{"name":"D\u00e9partement de Pharmacologie, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC H3C 3J7, Canada."},{"name":"School of Recreation Management and Kinesiology, Acadia University, Wolfville, NS B4P 2R6, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Rousseau","sequence":"additional","affiliation":[{"name":"Department of Biology, Acadia University, Wolfville, NS B4P 2R6, Canada."},{"name":"D\u00e9partement de Pharmacologie, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC H3C 3J7, Canada."},{"name":"School of Recreation Management and Kinesiology, Acadia University, Wolfville, NS B4P 2R6, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathon R.","family":"Fowles","sequence":"additional","affiliation":[{"name":"Department of Biology, Acadia University, Wolfville, NS B4P 2R6, Canada."},{"name":"D\u00e9partement de Pharmacologie, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC H3C 3J7, Canada."},{"name":"School of Recreation Management and Kinesiology, Acadia University, Wolfville, NS B4P 2R6, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9 J.L.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Biology, Acadia University, Wolfville, NS B4P 2R6, Canada."},{"name":"D\u00e9partement de Pharmacologie, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC H3C 3J7, Canada."},{"name":"School of Recreation Management and Kinesiology, Acadia University, Wolfville, NS B4P 2R6, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"atypb1\/ref1","doi-asserted-by":"crossref","first-page":"S265","DOI":"10.1055\/s-2007-972723","volume":"18","author":"Booth F.W.","year":"1997","journal-title":"Int. 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