{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:09:11Z","timestamp":1765886951700},"reference-count":36,"publisher":"Canadian Science Publishing","issue":"5","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Appl. Physiol. Nutr. Metab."],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p> Obesity and inactivity are associated with endothelial dysfunction that may contribute to the development of atherosclerosis. We examined the effects of a short-term lifestyle intervention on circulating biomarkers of endothelial health. Nineteen overweight or obese (mean body mass index (BMI): 28.9\u00a0\u00b1 0.7\u00a0kg\/m<jats:sup>2<\/jats:sup>) men and women underwent 6\u00a0weeks of body mass reduction induced by moderate energy restriction (~750\u00a0kcal\/d; 1 kcal = 4.184 kJ) and aerobic training (~400\u00a0kcal\/d). Fasting serum samples were collected at baseline and after reduction in body mass (week 6) to assess concentrations of nitrotyrosine (NT), secretory phospholipase A<jats:sub>2<\/jats:sub> (sPLA<jats:sub>2<\/jats:sub>), and soluble intracellular adhesion molecule-1 (sICAM-1). Body mass was significantly reduced from 81.3\u00a0\u00b1 2.8 to 77.3\u00a0\u00b1 2.6\u00a0kg (p\u00a0&lt; 0.05). Circulating concentrations of NT and sICAM-1 were significantly reduced with treatment (~25% and ~10%, respectively), whereas sPLA<jats:sub>2<\/jats:sub> levels were significantly elevated (~45%). Elevations in sPLA<jats:sub>2<\/jats:sub> were negatively correlated with changes in NT (r =\u00a0\u20130.58, p = 0.047); reductions in NT did not correlate significantly with reductions in sICAM-1. It appears that circulating markers of endothelial health are susceptible to short-term exercise interventions with modest reduction in body mass, and such a lifestyle modification may improve endothelial health by reducing protein nitration products and cellular adhesion. <\/jats:p>","DOI":"10.1139\/h06-040","type":"journal-article","created":{"date-parts":[[2006,11,16]],"date-time":"2006-11-16T15:45:42Z","timestamp":1163691942000},"page":"512-517","source":"Crossref","is-referenced-by-count":13,"title":["Short-term lifestyle modification alters circulating biomarkers of endothelial health in sedentary, overweight adults"],"prefix":"10.1139","volume":"31","author":[{"given":"R. Scott","family":"Rector","sequence":"first","affiliation":[{"name":"Department of Nutritional Sciences, University of Missouri, Columbia, MO 65211 USA."},{"name":"Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211 USA."},{"name":"Department of Biochemistry, University of Missouri, Columbia, MO 65211 USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R.","family":"Turk","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, University of Missouri, Columbia, MO 65211 USA."},{"name":"Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211 USA."},{"name":"Department of Biochemistry, University of Missouri, Columbia, MO 65211 USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace Y.","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, University of Missouri, Columbia, MO 65211 USA."},{"name":"Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211 USA."},{"name":"Department of Biochemistry, University of Missouri, Columbia, MO 65211 USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brianne L.","family":"Guilford","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, University of Missouri, Columbia, MO 65211 USA."},{"name":"Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211 USA."},{"name":"Department of Biochemistry, University of Missouri, Columbia, MO 65211 USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian W.","family":"Toedebusch","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, University of Missouri, Columbia, MO 65211 USA."},{"name":"Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211 USA."},{"name":"Department of Biochemistry, University of Missouri, Columbia, MO 65211 USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matt W.","family":"McClanahan","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, University of Missouri, Columbia, MO 65211 USA."},{"name":"Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211 USA."},{"name":"Department of Biochemistry, University of Missouri, Columbia, MO 65211 USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom R.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, University of Missouri, Columbia, MO 65211 USA."},{"name":"Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211 USA."},{"name":"Department of Biochemistry, University of Missouri, Columbia, MO 65211 USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"atypb1\/ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000025562"},{"key":"atypb2\/ref2","unstructured":"American College of Sport Medicine. 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