{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:03:44Z","timestamp":1762160624201},"reference-count":36,"publisher":"Canadian Science Publishing","issue":"3","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Appl. Physiol. Nutr. Metab."],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:p>Aging increases injury susceptibility and impairs the ability to adapt to repetitive exposures of mechanical loading. The objective of this research was to investigate if movement velocity affects muscle response to a chronic administration of stretch\u2013shortening cycles (SSCs) differently in young vs. old rats. Dorsiflexor muscles of old (30\u00a0months, n = 5) and young rats (12\u00a0weeks, n = 6) were exposed 3 times\/week for 4.5 weeks to a protocol of 80 maximal SSCs per exposure in vivo. Skeletal muscle response was characterized by high- (500\u00b0\/s) and low- (60\u00b0\/s) velocity dynamic performance, which was evaluated using peak eccentric force, isometric pre-stretch force, eccentric force enhancement above the isometric pre-stretch force, negative work, and positive work. The performance of the young and old groups was not statistically different at the start of the exposure. By the end of the exposure, however, a statistical difference was noted\u2014performance increased significantly in the young animals and decreased significantly in the old animals. The SSC velocity had a profound effect on muscle response. The young animals\u2019 high- and low-velocity performances increased during the chronic exposure period, whereas the old animals\u2019 performances declined. High-velocity performance increased more than low-velocity performance in young animals. In contrast, old animals suffered the most loss in high-velocity performance over the chronic exposure period. A chronic exposure of SSCs results in a significant performance increase in young animals, and a significant performance decrease in old animals. These differences are more profound during high-velocity movements. These findings suggest that age may impair the ability of skeletal muscle to adapt to repetitive mechanical loading, particularly during high-velocity movements.<\/jats:p>","DOI":"10.1139\/h07-014","type":"journal-article","created":{"date-parts":[[2007,5,18]],"date-time":"2007-05-18T07:53:15Z","timestamp":1179474795000},"page":"443-453","source":"Crossref","is-referenced-by-count":11,"title":["The influence of velocity of stretch\u2013shortening contractions on muscle performance during chronic exposure: age effects"],"prefix":"10.1139","volume":"32","author":[{"given":"Robert G.","family":"Cutlip","sequence":"first","affiliation":[{"name":"National Institute for Occupational Safety and Health (NIOSH), Health Effects Laboratory Division, Morgantown, WV 26506, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brent A.","family":"Baker","sequence":"additional","affiliation":[{"name":"National Institute for Occupational Safety and Health (NIOSH), Health Effects Laboratory Division, Morgantown, WV 26506, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken B.","family":"Geronilla","sequence":"additional","affiliation":[{"name":"National Institute for Occupational Safety and Health (NIOSH), Health Effects Laboratory Division, Morgantown, WV 26506, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael L.","family":"Kashon","sequence":"additional","affiliation":[{"name":"National Institute for Occupational Safety and Health (NIOSH), Health Effects Laboratory Division, Morgantown, WV 26506, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John Z.","family":"Wu","sequence":"additional","affiliation":[{"name":"National Institute for Occupational Safety and Health (NIOSH), Health Effects Laboratory Division, Morgantown, WV 26506, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"atypb1\/ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s004210050438"},{"key":"atypb2\/ref2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006824324509"},{"key":"atypb3\/ref3","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1249\/00005768-199405000-00006","volume":"26","author":"Booth F.W.","year":"1994","journal-title":"Med. 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