{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:37:10Z","timestamp":1783557430065,"version":"3.55.0"},"reference-count":32,"publisher":"Canadian Science Publishing","issue":"1","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Appl. Physiol. Nutr. Metab."],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:p> The purpose of this study was to assess the potential impact of weight loss up to a state of plateau on symptoms of depression. Eleven obese men (mean body mass index (BMI) = 33.4\u00a0kg\u00b7m<jats:sup>\u20132<\/jats:sup>, mean age = 38\u00a0y) participated in this repeated-measures, within-subjects, clinical intervention. They were subjected to a weight-loss program that consisted of a supervised diet and exercise clinical intervention. The phases investigated were (i) baseline; (ii) after 5\u00a0\u00b1 1\u00a0kg loss of body mass (phase 1); (iii) after 10\u00a0\u00b1 1\u00a0kg weight loss (phase 2); and (iv) at resistance to further weight loss (plateau). At each phase of the weight-reducing program, glucose homeostasis markers were determined using an oral glucose tolerance test (OGTT). Serum thyroid-stimulating hormone (TSH), total triiodothyronine (T3), and free thyroxine (fT4) concentrations were also measured and the Beck Depression Inventory (BDI) was administered. The weight loss plateau occurred after 7.4\u00a0\u00b1 1.9\u00a0months of intervention and corresponded to a loss of 11.2% of initial body weight (93.9% of which was from fat stores). This amount of weight loss induced a significant decrease in resting metabolic rate (RMR) (p\u00a0&lt; 0.05) and a significant increase in desire to eat (p\u00a0&lt; 0.05) and in depression symptoms (p\u00a0&lt; 0.01) compared with baseline. Intriguingly, the glucose area below fasting values (G<jats:sub>ABF<\/jats:sub>) at plateau was significantly higher as compared with other phases of the program (p\u00a0&lt; 0.01). We found a strong negative correlation (r =\u00a0\u20130.77, p\u00a0&lt; 0.01) between the change in glucose concentrations at 180\u00a0min of the OGTT and the change in BDI scores between plateau and baseline values. Similarly, highly significant relationships were found between the change in T3 or fT4 concentrations and the change in BDI scores (r =\u00a0\u20130.71 and r =\u00a0\u20130.68, respectively; p\u00a0&lt; 0.01). Weight loss until plateauing is associated with a trend toward hypoglycemia at the end of the oral glucose challenge and with a decrease in T3 and fT4 levels. These physiological changes are shown to be highly linked with the increase in depression symptoms observed at plateau. Taken together, these data emphasize the relevance of caution and reasonable objectives when prescribing a weight reduction program to obese individuals. <\/jats:p>","DOI":"10.1139\/h07-137","type":"journal-article","created":{"date-parts":[[2008,3,17]],"date-time":"2008-03-17T20:06:23Z","timestamp":1205784383000},"page":"86-92","source":"Crossref","is-referenced-by-count":24,"title":["Increase in depression symptoms with weight loss: association with glucose homeostasis and thyroid function"],"prefix":"10.1139","volume":"33","author":[{"given":"Jean-Philippe","family":"Chaput","sequence":"first","affiliation":[{"name":"Division of Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Quebec City, QC G1K\u00a07P4."},{"name":"Department of Medicine, Division of Endocrinology, Centre hospitalier de l\u2019Universit\u00e9 Laval, Quebec City, QC G1V\u00a04G2."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Arguin","sequence":"additional","affiliation":[{"name":"Division of Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Quebec City, QC G1K\u00a07P4."},{"name":"Department of Medicine, Division of Endocrinology, Centre hospitalier de l\u2019Universit\u00e9 Laval, Quebec City, QC G1V\u00a04G2."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Gagnon","sequence":"additional","affiliation":[{"name":"Division of Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Quebec City, QC G1K\u00a07P4."},{"name":"Department of Medicine, Division of Endocrinology, Centre hospitalier de l\u2019Universit\u00e9 Laval, Quebec City, QC G1V\u00a04G2."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Tremblay","sequence":"additional","affiliation":[{"name":"Division of Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Quebec City, QC G1K\u00a07P4."},{"name":"Department of Medicine, Division of Endocrinology, Centre hospitalier de l\u2019Universit\u00e9 Laval, Quebec City, QC G1V\u00a04G2."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"atypb1\/ref2","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1017\/S0007114500000623","volume":"83","author":"Arvaniti K.","year":"2000","journal-title":"Br. 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