{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T20:35:16Z","timestamp":1774730116497,"version":"3.50.1"},"reference-count":35,"publisher":"Canadian Science Publishing","issue":"1","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Appl. Physiol. Nutr. Metab."],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:p> The purpose of this study is to describe patient-related variables in a cohort of advanced cancer patients (ACPs) enrolled in a home parenteral nutrition (HPN) program. This study reviewed the cohort of ACPs enrolled in the Northern Alberta Home Total Parenteral Nutrition Program (NAHTPNP). Thirty-eight ACPs received HPN during the study period, 24% of all patients admitted for PN. Of these, 27 (71%) were female. Mean age was 48.76 y (SD 13.8 y). Bowel obstruction was the most common indication for initiating HPN (84%, 32) and ovarian cancer was the most common malignancy (34%, 13). Patients who began HPN with a Karnofsky performance status (KPS) of greater than 50 (median of 70) were found to have a longer duration of life (median: 6 months) compared with patients who began HPN with a KPS of 50 or below (median = 50; median 3\u00a0months; p = 0.01; two-tailed). There was no difference in survival between malignancy type (p = NS). Advanced cancer is the fastest growing indication for enrollment in the HPN program. ACP demonstrated a 3% average annual increase proportionate to all indications for HPN starts, accounting for 7%\u201348% of HPN starts from 1999\u20132006. HPN is an increasingly used therapy for patients with advanced cancer, most commonly for intestinal failure in the setting of bowel obstruction. Initiation of HPN at a higher KPS was associated with a longer duration of life. Further studies are needed to validate the use of TPN in end-stage cancer patients. <\/jats:p>","DOI":"10.1139\/h07-152","type":"journal-article","created":{"date-parts":[[2008,3,17]],"date-time":"2008-03-17T16:06:23Z","timestamp":1205769983000},"page":"102-106","source":"Crossref","is-referenced-by-count":44,"title":["Use of parenteral nutrition in patients with advanced cancer"],"prefix":"10.1139","volume":"33","author":[{"given":"Isaac","family":"Soo","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Alberta, Edmonton, AB T6G 2E1."},{"name":"Division of Gastroenterology, Faculty of Medicine, University of Alberta, 323 CSC Royal Alexandra Hospital, Edmonton, AB T5H\u00a03V9."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leah","family":"Gramlich","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Alberta, Edmonton, AB T6G 2E1."},{"name":"Division of Gastroenterology, Faculty of Medicine, University of Alberta, 323 CSC Royal Alexandra Hospital, Edmonton, AB T5H\u00a03V9."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"atypb1\/ref1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/85.5.365"},{"key":"atypb2\/ref2","first-page":"61","volume":"6","author":"Ambrus J.L.","year":"1975","journal-title":"J. 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