{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:40:17Z","timestamp":1773272417566,"version":"3.50.1"},"reference-count":24,"publisher":"Canadian Science Publishing","issue":"4","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Appl. Physiol. Nutr. Metab."],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:p>Plant sterol (PS) consumption decreases low-density lipoprotein cholesterol (LDL-C) levels; however, high variability of responsiveness of lipid levels to PS intervention has been observed. We hypothesized that common single-nucleotide polymorphisms (SNPs) in the genes for the ATP binding cassette proteins G5 (ABCG5) and G8 (ABCG8), Niemann-Pick C1-like 1 (NPC1L1), or other proteins of the cholesterol pathway, would underline inter-individual variations in response to PS. Twenty-six hyperlipidemic subjects completed a randomized trial of 3 PS phases and a control phase. Three non-responders were identified who failed on 3 consecutive occasions to decrease either total cholesterol or LDL-C level vs. control. It was observed that after 3 PS phases compared with a control phase, cholesterol absorption changed to a lesser degree (\u20137.7%\u00a0\u00b1 10.8%) in the non-responders than in the top 3 responders (\u201322.1%\u00a0\u00b1 8.8%); however, cholesterol synthesis rates did not differ between sub-groups. No common polymorphisms in ABCG8, ABCG5, or NPC1L1 were demonstrated between the 3 top responders and the non-responders. Yet, 1 non-responsive subject did demonstrate a rare SNP in NPC1L1. Results indicate PS intake did not decrease cholesterol absorption rates to the same degree in certain subjects, possibly clarifying the inter-individual variability in the cholesterol-lowering effect; hence, this work should be expanded.<\/jats:p>","DOI":"10.1139\/h08-041","type":"journal-article","created":{"date-parts":[[2008,7,23]],"date-time":"2008-07-23T14:09:32Z","timestamp":1216822172000},"page":"728-734","source":"Crossref","is-referenced-by-count":26,"title":["Association between non-responsiveness to plant sterol intervention and polymorphisms in cholesterol metabolism genes: a case-control study"],"prefix":"10.1139","volume":"33","author":[{"given":"Iwona","family":"Rudkowska","sequence":"first","affiliation":[{"name":"School of Dietetics and Human Nutrition, Faculty of Agricultural and Environmental Sciences, McGill University, 21 111 Lakeshore Road, Ste-Anne-de-Bellevue, QC H9X\u00a03V9, Canada."},{"name":"Danone Research, Route Departementale 128, 91767\u00a0Palaiseau CEDEX, France."},{"name":"Richardson Centre for Functional Foods and Nutraceuticals, 196 Innovation Drive, Winnipeg, MB R3T\u00a06C5, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhad S.","family":"AbuMweis","sequence":"additional","affiliation":[{"name":"School of Dietetics and Human Nutrition, Faculty of Agricultural and Environmental Sciences, McGill University, 21 111 Lakeshore Road, Ste-Anne-de-Bellevue, QC H9X\u00a03V9, Canada."},{"name":"Danone Research, Route Departementale 128, 91767\u00a0Palaiseau CEDEX, France."},{"name":"Richardson Centre for Functional Foods and Nutraceuticals, 196 Innovation Drive, Winnipeg, MB R3T\u00a06C5, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Nicolle","sequence":"additional","affiliation":[{"name":"School of Dietetics and Human Nutrition, Faculty of Agricultural and Environmental Sciences, McGill University, 21 111 Lakeshore Road, Ste-Anne-de-Bellevue, QC H9X\u00a03V9, Canada."},{"name":"Danone Research, Route Departementale 128, 91767\u00a0Palaiseau CEDEX, France."},{"name":"Richardson Centre for Functional Foods and Nutraceuticals, 196 Innovation Drive, Winnipeg, MB R3T\u00a06C5, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.H.","family":"Jones","sequence":"additional","affiliation":[{"name":"School of Dietetics and Human Nutrition, Faculty of Agricultural and Environmental Sciences, McGill University, 21 111 Lakeshore Road, Ste-Anne-de-Bellevue, QC H9X\u00a03V9, Canada."},{"name":"Danone Research, Route Departementale 128, 91767\u00a0Palaiseau CEDEX, France."},{"name":"Richardson Centre for Functional Foods and Nutraceuticals, 196 Innovation Drive, Winnipeg, MB R3T\u00a06C5, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"atypb1\/ref1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1093131"},{"key":"atypb2\/ref2","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0022-2275(20)33370-8","volume":"40","author":"Bosner M.S.","year":"1999","journal-title":"J. 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