{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:40:43Z","timestamp":1790192443091,"version":"4.1.0"},"reference-count":62,"publisher":"Canadian Science Publishing","issue":"5","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Appl. Physiol. Nutr. Metab."],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:p>To investigate the ameliorative potential of sodium selenite and zinc sulfate on intensive-swimming-induced testicular disorders, 48 Wistar male rats (age, 4\u00a0months; mass, 146.2\u00a0\u00b1 3.6\u00a0g) were randomly divided into 4 groups: the unexercised-control group (n = 12); the exercised group (n = 12); the control supplemented group (n = 12); and the exercised supplemented group (n = 12). For 10 weeks, the exercised rats underwent a protocol that consisted of 4\u00a0h\u00b7d<jats:sup>\u20131<\/jats:sup>swimming, for 6\u00a0d\u00b7week<jats:sup>\u20131<\/jats:sup>; the control rats did not exercise. For 10 weeks, both the supplemented groups received an oral daily dose of a combination of sodium selenite and zinc sulfate (6\u00a0 and 3 mg\u00b7kg body mass<jats:sup>\u20131<\/jats:sup>, respectively). After 10 weeks, a significant reduction (p\u00a0&lt; 0.05) was seen in rats in the exercised group, compared with rats in both control groups, in paired testicular masses; in epididymal sperm count; in testicular \u0394<jats:sup>5<\/jats:sup>, 3\u03b2-hydroxysteroid dehydrogenase (HSD) and 17\u03b2-HSD; in plasma levels of testosterone, luteinizing hormone, follicle-stimulating hormone, and prolactin; in the numbers of preleptotine spermatocytes, midpachytene spermatocytes, and stage 7 spermatids of the stage VII seminiferous epithelium cycle; and in fertility performance. As well, a significant increase (p\u00a0&lt; 0.05) was seen in the exercised group, compared with both control groups, in plasma corticosterone levels and in testicular content of malondialdehyde and catalase activity. At the same time, there was a significant reduction (p\u00a0&lt; 0.05) in the exercised group, compared with both control groups, in plasma concentrations of zinc and selenium; in the testicular content of glutathione (GSH), the glutathione and glutathione disulphide (GSSG) ratio, ascorbic acid, and \u03b1-tocopherol; and in testicular activities of superoxide dismutase, glutathione-peroxidase, and glutathione-S-transferase in the testes. No significant changes were seen in the number of spermatogonia-A from the stage VII seminiferous epithelium cycle or the testicular content of GSSG among the groups. Sodium selenite and zinc sulfate supplementation significantly protected against exercise-induced testicular gamatogenic and spermatogenic disorders, prevented testicular oxidative stress, and increased antioxidant status. It can be concluded that intensive-swimming-induced oxidative stress causes dysfunctions in the male reproductive system, which can be protected by the coadministration of sodium selenite and zinc sulfate.<\/jats:p>","DOI":"10.1139\/h08-065","type":"journal-article","created":{"date-parts":[[2008,10,10]],"date-time":"2008-10-10T18:42:16Z","timestamp":1223664136000},"page":"903-914","source":"Crossref","is-referenced-by-count":35,"title":["Protective effect of sodium selenite and zinc sulfate on intensive swimming-induced testicular gamatogenic and steroidogenic disorders in mature male rats"],"prefix":"10.1139","volume":"33","author":[{"given":"Kuladip","family":"Jana","sequence":"first","affiliation":[{"name":"Garrison Institute on Aging, Texas Tech University Health Sciences Center, 3601 4th St., Lubbock, TX 79430, USA."},{"name":"West Bengal University of Animal and Fishery Sciences, 37 & 68, K.B. Sarani, Calcutta 700037, India."},{"name":"Department of Physiology, Janki Medical College, Janakpur, Nepal."},{"name":"Department of Physiology and Pathology, M.B. Kedia Dental College and Research Center, Birgunj, Nepal."},{"name":"Nilratan Sarkar Medical College and Hospital, 138, A.J.C. Bose Road, Calcutta 700014, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pravat K.","family":"Samanta","sequence":"additional","affiliation":[{"name":"Garrison Institute on Aging, Texas Tech University Health Sciences Center, 3601 4th St., Lubbock, TX 79430, USA."},{"name":"West Bengal University of Animal and Fishery Sciences, 37 & 68, K.B. Sarani, Calcutta 700037, India."},{"name":"Department of Physiology, Janki Medical College, Janakpur, Nepal."},{"name":"Department of Physiology and Pathology, M.B. Kedia Dental College and Research Center, Birgunj, Nepal."},{"name":"Nilratan Sarkar Medical College and Hospital, 138, A.J.C. Bose Road, Calcutta 700014, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indranil","family":"Manna","sequence":"additional","affiliation":[{"name":"Garrison Institute on Aging, Texas Tech University Health Sciences Center, 3601 4th St., Lubbock, TX 79430, USA."},{"name":"West Bengal University of Animal and Fishery Sciences, 37 & 68, K.B. Sarani, Calcutta 700037, India."},{"name":"Department of Physiology, Janki Medical College, Janakpur, Nepal."},{"name":"Department of Physiology and Pathology, M.B. Kedia Dental College and Research Center, Birgunj, Nepal."},{"name":"Nilratan Sarkar Medical College and Hospital, 138, A.J.C. Bose Road, Calcutta 700014, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasanta","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Garrison Institute on Aging, Texas Tech University Health Sciences Center, 3601 4th St., Lubbock, TX 79430, USA."},{"name":"West Bengal University of Animal and Fishery Sciences, 37 & 68, K.B. Sarani, Calcutta 700037, India."},{"name":"Department of Physiology, Janki Medical College, Janakpur, Nepal."},{"name":"Department of Physiology and Pathology, M.B. Kedia Dental College and Research Center, Birgunj, Nepal."},{"name":"Nilratan Sarkar Medical College and Hospital, 138, A.J.C. 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