{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T14:27:10Z","timestamp":1780496830437,"version":"3.54.1"},"reference-count":30,"publisher":"Canadian Science Publishing","issue":"4","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Appl. Physiol. Nutr. Metab."],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:p>The effects of increased training (IT) load on plasma concentrations of lipopolysaccharides (LPS), proinflammatory cytokines, and anti-LPS antibodies during exercise in the heat were investigated in 18 male runners, who performed 14\u00a0days of normal training (NT) or 14\u00a0days of 20% IT load in 2 equal groups. Before (trial 1) and after (trial 2) the training intervention, all subjects ran at 70% maximum oxygen uptake on a treadmill under hot (35\u00a0\u00b0C) and humid (\u223c40%) conditions, until core temperature reached 39.5\u00a0\u00b0C or volitional exhaustion. Venous blood samples were drawn before, after, and 1.5\u00a0h after exercise. Plasma LPS concentration after exercise increased by 71% (trial 1, p\u00a0&lt; 0.05) and 21% (trial\u00a02) in the NT group and by 92% (trial 1, p\u00a0&lt; 0.01) and 199% (trial 2, p\u00a0&lt; 0.01) in the IT group. Postintervention plasma LPS concentration was 35% lower before exercise (p\u00a0&lt; 0.05) and 47% lower during recovery (p\u00a0&lt; 0.01) in the IT than in the NT group. Anti-LPS IgM concentration during recovery was 35% lower in the IT than in the NT group (p\u00a0&lt; 0.05). Plasma interleukin (IL)-6 and tumor necrosis factor (TNF)-\u03b1 concentrations after exercise (IL-6, 3\u22127 times, p\u00a0&lt; 0.01, and TNF-\u03b1, 33%, p\u00a0&lt; 0.01) and during recovery (IL-6, 2\u22124 times, p\u00a0&lt; 0.05, and TNF-\u03b1, 30%, p\u00a0&lt; 0.01) were higher than at rest within each group. These data suggest that a short-term tolerable increase in training load may protect against developing endotoxemia during exercise in the heat.<\/jats:p>","DOI":"10.1139\/h09-021","type":"journal-article","created":{"date-parts":[[2009,9,18]],"date-time":"2009-09-18T15:57:04Z","timestamp":1253289424000},"page":"616-624","source":"Crossref","is-referenced-by-count":46,"title":["The effects of increased endurance training load on biomarkers of heat intolerance during intense exercise in the heat"],"prefix":"10.1139","volume":"34","author":[{"given":"Chin Leong","family":"Lim","sequence":"first","affiliation":[{"name":"School of Human Movement Studies, University of Queensland, St Lucia, 4072, Brisbane, Australia."},{"name":"Division of Health, Design, and Science, University of Canberra, ACT 2601 Canberra, Australia."},{"name":"Australian Institute of Sport, Leverrier St., Bruce ACT 2601, Canberra, Australia."},{"name":"Faculty of Sport Sciences, Waseda University, 2-579-15, Mikajima, Tokorozawa, Saitama 359-1192, Japan."},{"name":"Defence Medical and Environmental Research Institute, DSO National Labs, 27\u00a0Medical Drive, #09-01, Singapore 117510, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Pyne","sequence":"additional","affiliation":[{"name":"School of Human Movement Studies, University of Queensland, St Lucia, 4072, Brisbane, Australia."},{"name":"Division of Health, Design, and Science, University of Canberra, ACT 2601 Canberra, Australia."},{"name":"Australian Institute of Sport, Leverrier St., Bruce ACT 2601, Canberra, Australia."},{"name":"Faculty of Sport Sciences, Waseda University, 2-579-15, Mikajima, Tokorozawa, Saitama 359-1192, Japan."},{"name":"Defence Medical and Environmental Research Institute, DSO National Labs, 27\u00a0Medical Drive, #09-01, Singapore 117510, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy","family":"Horn","sequence":"additional","affiliation":[{"name":"School of Human Movement Studies, University of Queensland, St Lucia, 4072, Brisbane, Australia."},{"name":"Division of Health, Design, and Science, University of Canberra, ACT 2601 Canberra, Australia."},{"name":"Australian Institute of Sport, Leverrier St., Bruce ACT 2601, Canberra, Australia."},{"name":"Faculty of Sport Sciences, Waseda University, 2-579-15, Mikajima, Tokorozawa, Saitama 359-1192, Japan."},{"name":"Defence Medical and Environmental Research Institute, DSO National Labs, 27\u00a0Medical Drive, #09-01, Singapore 117510, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia","family":"Kalz","sequence":"additional","affiliation":[{"name":"School of Human Movement Studies, University of Queensland, St Lucia, 4072, Brisbane, Australia."},{"name":"Division of Health, Design, and Science, University of Canberra, ACT 2601 Canberra, Australia."},{"name":"Australian Institute of Sport, Leverrier St., Bruce ACT 2601, Canberra, Australia."},{"name":"Faculty of Sport Sciences, Waseda University, 2-579-15, Mikajima, Tokorozawa, Saitama 359-1192, Japan."},{"name":"Defence Medical and Environmental Research Institute, DSO National Labs, 27\u00a0Medical Drive, #09-01, Singapore 117510, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philo","family":"Saunders","sequence":"additional","affiliation":[{"name":"School of Human Movement Studies, University of Queensland, St Lucia, 4072, Brisbane, Australia."},{"name":"Division of Health, Design, and Science, University of Canberra, ACT 2601 Canberra, Australia."},{"name":"Australian Institute of Sport, Leverrier St., Bruce ACT 2601, Canberra, Australia."},{"name":"Faculty of Sport Sciences, Waseda University, 2-579-15, Mikajima, Tokorozawa, Saitama 359-1192, Japan."},{"name":"Defence Medical and Environmental Research 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Biological effects of endotoxin.InGut-derived infectious toxic shock. Current studies in hematology and blood transfusion.Edited byC.H. Kraft. Karger, Basel, Switzerland. pp.\u00a066\u221299."},{"key":"rg12\/ref12","first-page":"1090","volume":"54","author":"Dubose D.A.","year":"1983","journal-title":"Aviat. Space Environ. Med."},{"key":"rg13\/ref13","first-page":"R28","volume":"268","author":"Flanagan S.W.","year":"1995","journal-title":"Am. J. Physiol."},{"key":"rg14\/ref14","unstructured":"Greisman, S.E. 1983. Induction of endotoxin tolerance.InBeneficial effects of endotoxins.Edited byA. Nowotny. Plenum Press, New York, N.Y. pp.\u00a0149\u2212196."},{"key":"rg15\/ref15","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1152\/japplphysiol.00787.2001","volume":"92","author":"Lambert G.P.","year":"2002","journal-title":"J. Appl. 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