{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:57:32Z","timestamp":1790794652512,"version":"4.1.0"},"reference-count":37,"publisher":"Canadian Science Publishing","issue":"3","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Appl. Physiol. Nutr. Metab."],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:p> Cytosolic Ca<jats:sup>2+<\/jats:sup> transients associated with contraction and relaxation cycles in skeletal muscle are primarily dependent on the kinetics of Ca<jats:sup>2+<\/jats:sup> release and Ca<jats:sup>2+<\/jats:sup> uptake by the sarcoplasmic reticulum (SR). In humans, sarco(endo)plasmic reticulum Ca<jats:sup>2+<\/jats:sup>-ATPases (SERCAs) are solely responsible for the removal of Ca<jats:sup>2+<\/jats:sup> from the cytosol following muscle contraction. There are several signalling systems involved in the acute regulation of SERCAs required to achieve a given Ca<jats:sup>2+<\/jats:sup> transient during muscle contraction\u2013relaxation cycles. Cyclic-AMP-dependent protein kinase and Ca<jats:sup>2+<\/jats:sup>\/calmodulin-dependent protein kinase signalling activate SERCAs through the regulation of the endogenous SERCA-regulatory proteins, phospholamban and sarcolipin, both of which are highly expressed in human skeletal muscle. Recent studies on the regulation of SERCA2b in arterial smooth muscle and work from my laboratory on the interaction between SERCAs and the inducible 70-kDa heat shock protein suggests a novel role for redox signalling in regulating SERCA activity. In the absence of fatigue, activation of these signalling systems in response to repeated muscle activity serves to increase the rate of cytosolic free Ca<jats:sup>2+<\/jats:sup> ([Ca<jats:sup>2+<\/jats:sup>]<jats:sub>f<\/jats:sub>) decay (i.e., SR Ca<jats:sup>2+<\/jats:sup> uptake) and the speed of muscle relaxation. <\/jats:p>","DOI":"10.1139\/h09-033","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T11:15:15Z","timestamp":1242386115000},"page":"373-376","source":"Crossref","is-referenced-by-count":23,"title":["The decay phase of Ca<sup>2+<\/sup> transients in skeletal muscle: regulation and physiologyThis paper is one of a selection of papers published in this Special Issue, entitled 14th International Biochemistry of Exercise Conference\u00a0\u2013 Muscles as Molecular and Metabolic Machines, and has undergone the Journal\u2019s usual peer review process."],"prefix":"10.1139","volume":"34","author":[{"given":"A. 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