{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:17:26Z","timestamp":1791353846633,"version":"4.3.1"},"reference-count":49,"publisher":"Canadian Science Publishing","issue":"6","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Appl. Physiol. Nutr. Metab."],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:p>Excessive and exhausting physical loads depress the immune system. Carbohydrate consumption may minimize the postexercise suppression of the innate immune system. \u03b2-Glucan is a well-known immunomodulator, with positive effects on the functioning of immunocompetent cells. The goal of this study was to determine whether \u03b2-glucan dietary supplementation from the mushroom Pleurotus ostreatus decreases the suppressed immune system responses induced by short-term high-intensity exercise in humans. In this double-blind pilot study, 20 elite athletes were randomized to \u03b2-glucan (n = 9) or placebo (n = 11) groups; these groups consumed 100\u00a0mg of \u03b2-glucan (Imunoglukan) or placebo supplements, respectively, once a day for 2\u00a0months. Venous whole blood was collected before and after 2\u00a0months of supplementation (baseline), both immediately and 1\u00a0h after (recovery period) a 20-min intensive exercise bout at the end of the supplementation period. The blood samples were used to measure the cell counts of leukocytes, erythrocyte, and lymphocytes; subpopulations of lymphocytes, granulocytes, and monocytes; and natural killer (NK) cell activity (NKCA). A 28% reduction in NKCA (p\u00a0&lt; 0.01) below the baseline value was observed in the placebo group during the recovery period, whereas no significant reduction in NKCA was found in the \u03b2-glucan group. In addition, no significant decrease in NK cell count was measured in the \u03b2-glucan group during the recovery period. Immune cell counts did not differ significantly between the groups. These results indicate that insoluble \u03b2-glucan supplementation from P. ostreatus may play a role in modulating exercise-induced changes in NKCA in intensively training athletes.<\/jats:p>","DOI":"10.1139\/h10-070","type":"journal-article","created":{"date-parts":[[2010,12,22]],"date-time":"2010-12-22T16:07:36Z","timestamp":1293034056000},"page":"755-762","source":"Crossref","is-referenced-by-count":57,"title":["Effect of Pleuran (\u03b2-glucan from<i>Pleurotus ostreatus<\/i>) supplementation on cellular immune response after intensive exercise in elite athletes"],"prefix":"10.1139","volume":"35","author":[{"given":"Mari\u00e1n","family":"Bobov\u010d\u00e1k","sequence":"first","affiliation":[{"name":"Clinical Laboratory of Institute for Respiratory Disease, 5983 Nova Polianka-High Tatras, Slovakia."},{"name":"Pleuran, s.r.o, S\u00fakenn\u00edcka 15, 821 09 Bratislava, Slovakia."},{"name":"Institute of Zoology, Slovak Academy of Sciences, D\u00fabravsk\u00e1 cesta 9, 845 06 Bratislava, Slovakia; Department of Microbiology, Slovak Medical University, Limbova 14, 833 03 Bratislava, Slovakia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Kuniakov\u00e1","sequence":"additional","affiliation":[{"name":"Clinical Laboratory of Institute for Respiratory Disease, 5983 Nova Polianka-High Tatras, Slovakia."},{"name":"Pleuran, s.r.o, S\u00fakenn\u00edcka 15, 821 09 Bratislava, Slovakia."},{"name":"Institute of Zoology, Slovak Academy of Sciences, D\u00fabravsk\u00e1 cesta 9, 845 06 Bratislava, Slovakia; Department of Microbiology, Slovak Medical University, Limbova 14, 833 03 Bratislava, Slovakia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e1n","family":"Gabri\u017e","sequence":"additional","affiliation":[{"name":"Clinical Laboratory of Institute for Respiratory Disease, 5983 Nova Polianka-High Tatras, Slovakia."},{"name":"Pleuran, s.r.o, S\u00fakenn\u00edcka 15, 821 09 Bratislava, Slovakia."},{"name":"Institute of Zoology, Slovak Academy of Sciences, D\u00fabravsk\u00e1 cesta 9, 845 06 Bratislava, Slovakia; Department of Microbiology, Slovak Medical University, Limbova 14, 833 03 Bratislava, Slovakia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juraj","family":"Majt\u00e1n","sequence":"additional","affiliation":[{"name":"Clinical Laboratory of Institute for Respiratory Disease, 5983 Nova Polianka-High Tatras, Slovakia."},{"name":"Pleuran, s.r.o, S\u00fakenn\u00edcka 15, 821 09 Bratislava, Slovakia."},{"name":"Institute of Zoology, Slovak Academy of Sciences, D\u00fabravsk\u00e1 cesta 9, 845 06 Bratislava, Slovakia; Department of Microbiology, Slovak Medical University, Limbova 14, 833 03 Bratislava, Slovakia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"issue":"4","key":"rg1\/ref1","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1123\/ijsnem.11.4.490","volume":"11","author":"Bishop N.C.","year":"2001","journal-title":"Int. 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