{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T22:31:14Z","timestamp":1726439474158},"reference-count":37,"publisher":"Canadian Science Publishing","issue":"3","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Appl. Physiol. Nutr. Metab."],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p> Undernutrition during critical stages of development and childhood has important effects on cardiovascular homeostasis. The present study was undertaken to evaluate the in vivo and ex vivo cardiac function of rats submitted to postnatal protein restriction. Male Wistar rats (28\u00a0days old) were fed a regular (20%) or low-protein (6%) diet over 5\u00a0weeks. After this period, cardiac function was analyzed by echocardiography and isolated heart preparation. Furthermore, the density of cardiac noradrenergic fibers and hematological profile were evaluated. We found that malnourished rats exhibited elevated arterial blood pressure, increased fractional shortening (echocardiography), increased systolic tension, increased\u00a0\u00b1dT\/dt (isolated heart technique), impaired diastolic function characterized by a slight increase in the left ventricular end-diastolic diameter (echocardiography) and decreased diastolic tension (isolated heart technique), and cardiac hypertrophy evidenced by augmentation of the posterior left ventricular wall and discrete hematological changes. In addition, malnourished rats exhibited increased noradrenergic fiber density in their hearts (0.08%\u00a0\u00b1 0.02% area in control rats vs. 0.17%\u00a0\u00b1 0.03% area in malnourished rats). Our current data demonstrate that postnatal protein restriction causes cardiac adaptation characterized by an early overworking heart. This is at least in part mediated by an increase in the efferent sympathetic fibers to the heart. These findings provide important information for efforts to prevent and manage the consequences of undernutrition in the human population. <\/jats:p>","DOI":"10.1139\/h2012-017","type":"journal-article","created":{"date-parts":[[2012,5,2]],"date-time":"2012-05-02T14:30:41Z","timestamp":1335969041000},"page":"455-462","source":"Crossref","is-referenced-by-count":4,"title":["Cardiac responses of rats submitted to postnatal protein restriction"],"prefix":"10.1139","volume":"37","author":[{"given":"Tatiane Mois\u00e9s","family":"Mur\u00e7a","sequence":"first","affiliation":[{"name":"Universidade Federal de Minas Gerais, Av. Ant\u00f4nio Carlos 6627, Belo Horizonte 31.270-901, MG, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana Soares dos Reis","family":"Magno","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Av. Ant\u00f4nio Carlos 6627, Belo Horizonte 31.270-901, MG, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilda Luz de Andrade","family":"De Maria","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Av. Ant\u00f4nio Carlos 6627, Belo Horizonte 31.270-901, MG, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina Andrade Bragan\u00e7a","family":"Capuru\u00e7o","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Av. 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