{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:52:02Z","timestamp":1773010322529,"version":"3.50.1"},"reference-count":18,"publisher":"Canadian Science Publishing","issue":"5","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Appl. Physiol. Nutr. Metab."],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p> The aim of this study was to assess red blood cell glutathione from insulin-sensitive and insulin-resistant individuals before and after an oral glucose dose. Fifteen healthy, young (24\u00a0\u00b1 5\u00a0years), nonobese (23\u00a0\u00b1 2\u00a0kg\u00b7m<jats:sup>\u20132<\/jats:sup>), insulin-sensitive (ISI composite\u00a0= 6.0\u00a0\u00b1 1.2) individuals and 14 healthy, young (22\u00a0\u00b1 2\u00a0years), nonobese (24\u00a0\u00b1 2\u00a0kg\u00b7m<jats:sup>\u20132<\/jats:sup>), insulin-resistant (ISI composite\u00a0= 2.7\u00a0\u00b1 1.1) individuals received a 75 g oral glucose dose. Blood samples were drawn before and for 2\u00a0h after glucose ingestion for red blood cell glutathione and serum glucose and insulin concentrations. Glycemia before and after glucose ingestion was similar between groups (p\u00a0= 0.17), which suggest that hyperinsulinemia compensated impaired insulin sensitivity. Red blood cell total (p\u00a0= 0.81), reduced (p\u00a0= 0.79), and oxidized (p\u00a0= 0.88) glutathione concentrations were similar between groups under fasting and postprandial conditions. However, in response to glucose, increases in total and reduced glutathione concentrations were found at the end of the 2 h assessment period in both groups (p\u00a0&lt; 0.05). Direct associations between postprandial glucose response and red blood cell total (r\u00a0= 0.52; p\u00a0&lt; 0.05) and oxidized (r\u00a0= 0.61; p\u00a0= 0.02) glutathione concentrations were observed only in insulin-sensitive subjects. In conclusion, healthy individuals differing in their degree of insulin resistance showed similar red blood cell glutathione concentrations under non-glucose- and glucose-stimulated conditions. <\/jats:p>","DOI":"10.1139\/h2012-086","type":"journal-article","created":{"date-parts":[[2012,8,21]],"date-time":"2012-08-21T13:53:00Z","timestamp":1345557180000},"page":"997-1002","source":"Crossref","is-referenced-by-count":1,"title":["Assessment of red blood cell glutathione status in insulin resistance"],"prefix":"10.1139","volume":"37","author":[{"given":"Jose E.","family":"Galgani","sequence":"first","affiliation":[{"name":"Department of Nutrition, Faculty of Medicine, University of Chile, Independencia 1027, Clasificador 7, Santiago, Chile."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karla","family":"Vasquez","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Faculty of Medicine, University of Chile, Independencia 1027, Clasificador 7, Santiago, Chile."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giannella","family":"Leonelli","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Faculty of Medicine, University of Chile, Independencia 1027, Clasificador 7, Santiago, Chile."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandra","family":"Espinosa","sequence":"additional","affiliation":[{"name":"School of Medical Technology, Faculty of Medicine, University of Chile, Independencia 1027, Clasificador 7, Santiago, Chile."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hector","family":"Araya","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Faculty of Medicine, University of Chile, Independencia 1027, Clasificador 7, Santiago, Chile."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Perez-Bravo","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Faculty of Medicine, University of Chile, Independencia 1027, Clasificador 7, Santiago, Chile."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-S062"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI37048"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(97)90216-X"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2006.01.003"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1139\/y93-111"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(98)90357-2"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2010.50"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2010.70"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.12.8.544"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1038\/nature04634"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2009.08.009"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.090083297"},{"key":"refg13\/ref13","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.9.1462"},{"key":"refg14\/ref14","doi-asserted-by":"publisher","DOI":"10.1126\/science.1439783"},{"key":"refg15\/ref15","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.378"},{"key":"refg16\/ref16","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106704"},{"key":"refg17\/ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2005.06.011"},{"key":"refg18\/ref18","doi-asserted-by":"publisher","DOI":"10.1096\/fj.09-136572"}],"container-title":["Applied Physiology, Nutrition, and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/full-xml\/10.1139\/h2012-086","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/h2012-086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T03:14:21Z","timestamp":1578280461000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/h2012-086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1139\/h2012-086"],"URL":"https:\/\/doi.org\/10.1139\/h2012-086","relation":{},"ISSN":["1715-5312","1715-5320"],"issn-type":[{"value":"1715-5312","type":"print"},{"value":"1715-5320","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}