{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T02:39:20Z","timestamp":1774579160653,"version":"3.50.1"},"reference-count":26,"publisher":"Canadian Science Publishing","issue":"4","license":[{"start":{"date-parts":[[1996,8,1]],"date-time":"1996-08-01T00:00:00Z","timestamp":838857600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Appl. Physiol."],"published-print":{"date-parts":[[1996,8,1]]},"abstract":"<jats:p> The purpose of this study was to measure the contribution of the peripheral chemoreceptor (pR<jats:sub>c<\/jats:sub>) to [Formula: see text] during the steady-state of moderate-intensity cycle ergometer exercise using continuous hyperoxic suppression of pR<jats:sub>c<\/jats:sub> drive, while stabilizing the drive from the central chemoreceptor by clamping end-tidal PCO<jats:sub>2<\/jats:sub> (P<jats:sub>ET<\/jats:sub>CO<jats:sub>2<\/jats:sub>) at the peak level attained during the hyperoxic period of a poikilocapnic ride. In the isocapnic protocol, the P<jats:sub>ET<\/jats:sub>CO<jats:sub>2<\/jats:sub> was maintained at a constant level by a negative feedback, open loop system. Five subjects completed four repetitions of each of the poikilocapnic and isocapnic protocols. In the poikilocapnic protocol, [Formula: see text] declined following the step into hyperoxia and then began to increase, whereas the decline in [Formula: see text] was maintained in the isocapnic protocol. However, the mean decrease in [Formula: see text] was not significantly different between the poikilocapnic (16.1\u2002\u00b1\u20025.0%) and isocapnic (14.9\u2002\u00b1\u20024.4%) protocols. These results suggest that the declining phase of [Formula: see text] is fully complete before the secondary central stimulating actions of hyperoxia on [Formula: see text] and that the pR<jats:sub>c<\/jats:sub> contributes about 15% of the drive to breathe in moderate intensity exercise. Key words: ventilatory control, carotid bodies, hyperoxia <\/jats:p>","DOI":"10.1139\/h96-025","type":"journal-article","created":{"date-parts":[[2009,6,3]],"date-time":"2009-06-03T16:02:26Z","timestamp":1244044946000},"page":"285-300","source":"Crossref","is-referenced-by-count":7,"title":["Peripheral Chemoreflex Drive in Moderate-Intensity Exercise"],"prefix":"10.1139","volume":"21","author":[{"given":"Claudette M. 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