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These symptom domains are dimensionally distributed in the general population and are hypothesized to reflect both overlapping and distinct structural and functional features of cortical and subcortical brain networks.<\/jats:p>\n                  <jats:p>Methods: We applied a dimensional symptom approach in a sample of adults with ADHD ( n\u00a0=\u00a071) and healthy controls ( n\u00a0=\u00a059) to investigate structural brain correlates of inattention and emotional instability, as measured by the Brown Attention-Deficit Disorder Scales. Structural magnetic resonance imaging (MRI) data were analysed to examine cortical and subcortical associations with these symptom dimensions. Performance in an emotional Stroop task was assessed in conjunction with MRI acquisition in a subsample to explore neural correlates of emotion-related cognitive control. Data were collected between 2012 and 2017.<\/jats:p>\n                  <jats:p>Results: Emotional instability was negatively associated with nucleus accumbens volume, independent of inattention symptoms and ADHD diagnosis ( \u03b2 = \u22120.29, p\u00a0=\u00a00.016). Additionally, while controlling for inattention symptoms, a negative correlation between emotional instability and cortical surface area was found in a cluster comprising the left dorsolateral prefrontal cortex and right medial\/superior frontal cortex. Moreover, cortical thickness in the lateral orbitofrontal cortex was positively associated with performance in the Stroop task in ADHD ( r\u00a0=\u00a00.44, p\u00a0=\u00a00.027) while being negatively associated in healthy controls ( r = \u22120.40 p\u00a0=\u00a00.028).<\/jats:p>\n                  <jats:p>Limitations: Medication use within the ADHD group might influence brain-symptom-associations. The cross-sectional design of the study precludes conclusions about causality.<\/jats:p>\n                  <jats:p>Conclusions: These findings suggest that structural alterations in the nucleus accumbens are more strongly related to emotional, rather than attentional symptoms after accounting for their shared variance. Furthermore, altered prefrontal and orbitofrontal morphology may underlie impairments in emotional regulation, supporting the role of frontostriatal circuits in the dimensional expression of emotional instability across clinical and non-clinical populations.<\/jats:p>","DOI":"10.1139\/jpn-2025-0198","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T21:38:58Z","timestamp":1779485938000},"page":"1-10","source":"Crossref","is-referenced-by-count":0,"title":["Specific frontostriatal structural alterations underlie emotional instability but not inattention in ADHD and healthy individuals"],"prefix":"10.1139","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9189-6687","authenticated-orcid":false,"given":"Anna Luisa","family":"Klahn","sequence":"first","affiliation":[{"name":"University of Gothenburg","place":["Gothenburg, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frida","family":"Bayard","sequence":"additional","affiliation":[{"name":"Karolinska Institutet","place":["Stockholm, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Ab\u00e9","sequence":"additional","affiliation":[{"name":"Karolinska Institutet","place":["Stockholm, Sweden"]},{"name":"Pharmo Institute","place":["Lumanity, The Netherlands"]},{"name":"Quantify Research","place":["Stockholm, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Henje","sequence":"additional","affiliation":[{"name":"Ume\u00e5 University","place":["Ume\u00e5, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orestis","family":"Floros","sequence":"additional","affiliation":[{"name":"Karolinska Institutet","place":["Stockholm, Sweden"]},{"name":"Stockholm Center for Dependency Disorders, Lifestyle Treatment Unit","place":["Stockholm, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Ingvar","sequence":"additional","affiliation":[{"name":"Karolinska Institutet","place":["Stockholm, Sweden"]},{"name":"Karolinska University Hospital","place":["Stockholm, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Land\u00e9n","sequence":"additional","affiliation":[{"name":"University of Gothenburg","place":["Gothenburg, Sweden"]},{"name":"Karolinska Institutet","place":["Stockholm, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Predrag","family":"Petrovic","sequence":"additional","affiliation":[{"name":"Karolinska Institutet","place":["Stockholm, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-024-00495-0"},{"key":"refg2\/ref2","doi-asserted-by":"crossref","DOI":"10.1176\/appi.books.9780890425596","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"2013"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.02.006"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2016.00070"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.09.023"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.107.035782"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0248-5"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2006.01.011"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.13070966"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.10.011"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.08.031"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0202-6"},{"issue":"3","key":"refg13\/ref13","first-page":"290","volume":"6","author":"Floros O.","year":"2021","journal-title":"Biol. 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