{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T12:25:28Z","timestamp":1648643128418},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"6","license":[{"start":{"date-parts":[[1968,6,1]],"date-time":"1968-06-01T00:00:00Z","timestamp":-50025600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Microbiol."],"published-print":{"date-parts":[[1968,6,1]]},"abstract":"<jats:p> Classical and food-poisoning strains of Clostridium perfringens type A were tested for their capacity to produce gas gangrene in guinea pigs.The virulence of food-poisoning strains producing heat-sensitive spores and showing beta hemolysis on sheep-blood agar was comparable to that of the classical strains. The most virulent strains of both groups produced fatal infection with only three to five vegetative cells. Of 13 food-poisoning, heat-sensitive strains showing no beta hemolysis, only three were lethal when a minimum of 4\u2002\u00d7\u200210<jats:sup>4<\/jats:sup> to 4\u2002\u00d7\u200210<jats:sup>8<\/jats:sup> cells was injected. None of the food-poisoning, heat-resistant strains produced fatal infection with cell numbers up to 4\u2002\u00d7\u200210<jats:sup>8<\/jats:sup>. The groups of strains showed a correlation between virulence and formation of alpha toxin in liquid culture.It is concluded that a number of heat-sensitive, beta-hemolytic strains of C. perfringens may cause gas gangrene as well as food poisoning, and that the current subdivision of C. perfringens type A strains into classical and food-poisoning groups is no longer tenable. <\/jats:p>","DOI":"10.1139\/m68-117","type":"journal-article","created":{"date-parts":[[2010,2,8]],"date-time":"2010-02-08T16:20:11Z","timestamp":1265646011000},"page":"705-709","source":"Crossref","is-referenced-by-count":10,"title":["Experimental gas gangrene with food-poisoning Clostridium perfringens type A"],"prefix":"10.1139","volume":"14","author":[{"given":"A. H. W.","family":"Hauschild","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. S.","family":"Thatcher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/m68-117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T06:18:57Z","timestamp":1578291537000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/m68-117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1968,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1968,6,1]]}},"alternative-id":["10.1139\/m68-117"],"URL":"https:\/\/doi.org\/10.1139\/m68-117","relation":{},"ISSN":["0008-4166","1480-3275"],"issn-type":[{"value":"0008-4166","type":"print"},{"value":"1480-3275","type":"electronic"}],"subject":[],"published":{"date-parts":[[1968,6,1]]}}}