{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T16:14:41Z","timestamp":1779898481720,"version":"3.53.1"},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"2","license":[{"start":{"date-parts":[[1974,2,1]],"date-time":"1974-02-01T00:00:00Z","timestamp":128908800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Microbiol."],"published-print":{"date-parts":[[1974,2,1]]},"abstract":"<jats:p> There was no significant difference in serological titers when different groups of guinea pigs (Hartley strain) infected with varying doses of mycelial phase of Histoplasma duboisii (one, two, seven, and no injections) were superinfected with Listeria monocytogenes 6 months later. The immunological response of infected animals which received two biweekly intraperitoneal injections of Histoplasma duboisii and were superinfected after 40 days with homologous and heterologous organisms was used for comparison. In general, animals receiving a single injection of Histoplasma duboisii had no complement-fixing antibodies against this antigen; however, positive skin and precipitin reactions did occur. Animals receiving several injections of Histoplasma duboisii had a higher complement-fixation titer (1:16 to 1:256) than those with two injections (1:8 to 1:32). After superinfection with Listeria monocytogenes, animals which received seven injections of Histoplasma duboisii showed a slight reduction in the number of rosette-forming cells against Listeria monocytogenes antigens when compared with the controls. <\/jats:p>","DOI":"10.1139\/m74-024","type":"journal-article","created":{"date-parts":[[2010,4,30]],"date-time":"2010-04-30T18:45:31Z","timestamp":1272653131000},"page":"149-154","source":"Crossref","is-referenced-by-count":1,"title":["Immunological response of guinea pigs experimentally infected with <i>Histoplasma duboisii<\/i>"],"prefix":"10.1139","volume":"20","author":[{"given":"Raza","family":"Aly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard W.","family":"Larsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","container-title":["Canadian Journal of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/m74-024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T05:04:44Z","timestamp":1578287084000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/m74-024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1974,2,1]]}},"alternative-id":["10.1139\/m74-024"],"URL":"https:\/\/doi.org\/10.1139\/m74-024","relation":{},"ISSN":["0008-4166","1480-3275"],"issn-type":[{"value":"0008-4166","type":"print"},{"value":"1480-3275","type":"electronic"}],"subject":[],"published":{"date-parts":[[1974,2,1]]}}}