{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:15:57Z","timestamp":1760645757712},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"11","license":[{"start":{"date-parts":[[1981,11,1]],"date-time":"1981-11-01T00:00:00Z","timestamp":373420800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Microbiol."],"published-print":{"date-parts":[[1981,11,1]]},"abstract":"<jats:p> The successful production of disease in mice by a type III group B streptococcus is described in this report. When injected intravenously, 10<jats:sup>6<\/jats:sup> organisms produced a fulminating sepsis and resulted in 100% mortality within 48\u2002h. Inoculation of 10<jats:sup>8<\/jats:sup>\u201310<jats:sup>9<\/jats:sup> organisms directly onto the surface of the oropharynx progressed to bacteremia and meningitis in greater than 50% of animals. It*** a group of mice treated with penicillin immediately after oropharyngeal inoculation, the incidence of invasive bacteremia was reduced to 30%. The use of this animal model for studying the pathogenesis and treatment of experimentally produced meningitis and eradication of oropharyngeal colonization is discussed. <\/jats:p>","DOI":"10.1139\/m81-180","type":"journal-article","created":{"date-parts":[[2010,5,20]],"date-time":"2010-05-20T18:27:10Z","timestamp":1274380030000},"page":"1150-1155","source":"Crossref","is-referenced-by-count":4,"title":["Type III group B streptococcal infections in mice: bacteremia and meningitis following oral inoculation"],"prefix":"10.1139","volume":"27","author":[{"given":"Jan L.","family":"Lounsbery","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lance R.","family":"Green","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolores","family":"Furtado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/m81-180","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T05:12:18Z","timestamp":1578287538000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/m81-180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,11,1]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1981,11,1]]}},"alternative-id":["10.1139\/m81-180"],"URL":"https:\/\/doi.org\/10.1139\/m81-180","relation":{},"ISSN":["0008-4166","1480-3275"],"issn-type":[{"value":"0008-4166","type":"print"},{"value":"1480-3275","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,11,1]]}}}