{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T15:31:26Z","timestamp":1772897486214,"version":"3.50.1"},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"11","license":[{"start":{"date-parts":[[1991,11,1]],"date-time":"1991-11-01T00:00:00Z","timestamp":688953600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Microbiol."],"published-print":{"date-parts":[[1991,11,1]]},"abstract":"<jats:p> The susceptibility of congenitally immunodeficient mice to a nonencapsulated strain of Cryptococcus neoformans (strain M7) was evaluated. Gnotobiotic mice with defined congenital defects in innate immunity (beige) or cell-mediated immunity (athymic) or with combined defects in innate and cellular immunity (beige athymic) were i.v. challenged with C. neoformans M7. The nonencapsulated strain of C. neoformans produced a persistant low-grade infection in the brains of all immunodeficient and immunocompetent mice used in this study. Immunocompetent mice (nu\/+;bg\/+) and immunodeficient bg\/bg mice readily cleared nonencapsulated cryptococci from their kidneys, liver, lungs, and spleen. In contrast to nu\/+ mice, nu\/nu mice had a reduced capacity to clear nonencapsulated cryptococci from their kidneys and liver after i.v. challenge. Both bg\/bg\u2013nu\/nu and bg\/bg\u2013nu\/+ mice developed a low-grade infection in their kidneys, liver, lungs, and spleen, which was maintained throughout the 21-day study. Persistent infections were not due to reversion to an encapsulated state. These data indicate that a capsule may not always be necessary for C. neoformans to survive, in vivo, in tissues of immunodeficient and immunocompetent mice. Key words: Cryptococcus neoformans, capsule, immunodeficient mice. <\/jats:p>","DOI":"10.1139\/m91-144","type":"journal-article","created":{"date-parts":[[2009,8,13]],"date-time":"2009-08-13T19:53:02Z","timestamp":1250193182000},"page":"834-839","source":"Crossref","is-referenced-by-count":11,"title":["Susceptibility of congenitally immunodeficient mice to a nonencapsulated strain of <i>Cryptococcus neoformans<\/i>"],"prefix":"10.1139","volume":"37","author":[{"given":"Cindy A.","family":"Salkowski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Balish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/m91-144","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T11:51:47Z","timestamp":1578225107000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/m91-144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,11,1]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1991,11,1]]}},"alternative-id":["10.1139\/m91-144"],"URL":"https:\/\/doi.org\/10.1139\/m91-144","relation":{},"ISSN":["0008-4166","1480-3275"],"issn-type":[{"value":"0008-4166","type":"print"},{"value":"1480-3275","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,11,1]]}}}