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One of the most remarkable achievements in the field has been the identification of the methyl-CpG-binding domain family of proteins, which provide mechanistic links between specific patterns of DNA methylation and histone modifications. Although many of the current data indicate that methyl-CpG-binding proteins play a key role in maintaining a transcriptionally inactive state of methylated genes, MBD4 is also known to be involved in excision repair of T:G mismatches. The latter is a member of this family of proteins and appears to play a role in reducing mutations at 5-methylcytosine. This review examines the contribution of methyl-CpG-binding proteins in the epigenetic pathway of cancer.Key words: methyl-CpG-binding, MeCP2, DNA methylation, Rett syndrome, cancer epigenetics. <\/jats:p>","DOI":"10.1139\/o05-035","type":"journal-article","created":{"date-parts":[[2005,8,8]],"date-time":"2005-08-08T18:44:25Z","timestamp":1123526665000},"page":"374-384","source":"Crossref","is-referenced-by-count":56,"title":["Methyl-CpG-binding proteins in cancer: blaming the DNA methylation messenger"],"prefix":"10.1139","volume":"83","author":[{"given":"Esteban","family":"Ballestar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manel","family":"Esteller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"p_48\/p_48_1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0378-1119(91)90197-J","volume":"106","author":"Aissani B.","year":"1991","journal-title":"Gene"},{"key":"p_49\/p_49_1","first-page":"313","volume":"6","author":"Allfrey V.G.","year":"1966","journal-title":"Proc. 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