{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T20:05:09Z","timestamp":1791662709914,"version":"4.3.4"},"reference-count":14,"publisher":"Canadian Science Publishing","issue":"3","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochem. Cell Biol."],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:p> Iron deficiency anemia (IDA) during pregnancy continues to be of world-wide concern. IDA is a risk factor for preterm delivery and subsequent low birth weight, and possibly for poor neonatal health. Iron supplementation in pregnancy is a widely recommended practice, yet intervention programs have met with many controversies. In our study, 300 women at different trimesters of pregnancy were enrolled in a trial of oral administration of ferrous sulfate (520\u00a0mg once a day) or 30% iron-saturated bovine lactoferrin (bLf) (100\u00a0mg twice a day). Pregnant women refusing treatment represented the control group. In this group hemoglobin and total serum iron values measured after 30\u00a0d without treatment decreased significantly, especially in women at 18\u201331\u00a0weeks of pregnancy. In contrast, after 30\u00a0d of oral administration of bLf, hemoglobin and total serum iron values increased and to a greater extent than those observed in women treated orally for 30\u00a0d with ferrous sulfate, independently of the trimester of pregnancy. Unlike ferrous sulfate, bLf did not result in any side effects. These findings lead us to hypothesize that lactoferrin could influence iron homeostasis directly or through other proteins involved in iron transport out of the intestinal cells into the blood. <\/jats:p>","DOI":"10.1139\/o06-040","type":"journal-article","created":{"date-parts":[[2006,8,12]],"date-time":"2006-08-12T17:00:28Z","timestamp":1155402028000},"page":"377-380","source":"Crossref","is-referenced-by-count":77,"title":["Oral administration of lactoferrin increases hemoglobin and total serum iron in pregnant womenThis paper is one of a selection of papers published in this Special Issue, entitled 7th International Conference on Lactoferrin: Structure, Function, and Applications, and has undergone the Journal's usual peer review process."],"prefix":"10.1139","volume":"84","author":[{"given":"Rosalba","family":"Paesano","sequence":"first","affiliation":[{"name":"Department of Obstetrician and Gynecology, University of Rome \u201cLa Sapienza\u201d, Via di Grottarossa 1035, 00189 Roma, Italy."},{"name":"Department of Public Health Sciences, University of Rome \u201cLa Sapienza\u201d, Piazzale A. Moro 5, 00185 Roma,\r Italy."},{"name":"Department of Experimental Medicine, II\u00b0 University of Naples, Costantinopoli 16, 80138 Napoli, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Torcia","sequence":"additional","affiliation":[{"name":"Department of Obstetrician and Gynecology, University of Rome \u201cLa Sapienza\u201d, Via di Grottarossa 1035, 00189 Roma, Italy."},{"name":"Department of Public Health Sciences, University of Rome \u201cLa Sapienza\u201d, Piazzale A. Moro 5, 00185 Roma,\r Italy."},{"name":"Department of Experimental Medicine, II\u00b0 University of Naples, Costantinopoli 16, 80138 Napoli, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Berlutti","sequence":"additional","affiliation":[{"name":"Department of Obstetrician and Gynecology, University of Rome \u201cLa Sapienza\u201d, Via di Grottarossa 1035, 00189 Roma, Italy."},{"name":"Department of Public Health Sciences, University of Rome \u201cLa Sapienza\u201d, Piazzale A. Moro 5, 00185 Roma,\r Italy."},{"name":"Department of Experimental Medicine, II\u00b0 University of Naples, Costantinopoli 16, 80138 Napoli, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrica","family":"Pacifici","sequence":"additional","affiliation":[{"name":"Department of Obstetrician and Gynecology, University of Rome \u201cLa Sapienza\u201d, Via di Grottarossa 1035, 00189 Roma, Italy."},{"name":"Department of Public Health Sciences, University of Rome \u201cLa Sapienza\u201d, Piazzale A. Moro 5, 00185 Roma,\r Italy."},{"name":"Department of Experimental Medicine, II\u00b0 University of Naples, Costantinopoli 16, 80138 Napoli, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Ebano","sequence":"additional","affiliation":[{"name":"Department of Obstetrician and Gynecology, University of Rome \u201cLa Sapienza\u201d, Via di Grottarossa 1035, 00189 Roma, Italy."},{"name":"Department of Public Health Sciences, University of Rome \u201cLa Sapienza\u201d, Piazzale A. Moro 5, 00185 Roma,\r Italy."},{"name":"Department of Experimental Medicine, II\u00b0 University of Naples, Costantinopoli 16, 80138 Napoli, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Moscarini","sequence":"additional","affiliation":[{"name":"Department of Obstetrician and Gynecology, University of Rome \u201cLa Sapienza\u201d, Via di Grottarossa 1035, 00189 Roma, Italy."},{"name":"Department of Public Health Sciences, University of Rome \u201cLa Sapienza\u201d, Piazzale A. Moro 5, 00185 Roma,\r Italy."},{"name":"Department of Experimental Medicine, II\u00b0 University of Naples, Costantinopoli 16, 80138 Napoli, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piera","family":"Valenti","sequence":"additional","affiliation":[{"name":"Department of Obstetrician and Gynecology, University of Rome \u201cLa Sapienza\u201d, Via di Grottarossa 1035, 00189 Roma, Italy."},{"name":"Department of Public Health Sciences, University of Rome \u201cLa Sapienza\u201d, Piazzale A. 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