{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T04:15:59Z","timestamp":1751516159477,"version":"3.41.0"},"reference-count":10,"publisher":"Canadian Science Publishing","issue":"2","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochem. Cell Biol."],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:p> Poststenting restenosis is a significant clinical problem that involves vascular smooth muscle cell (VSMC) proliferation. We primarily investigated the effect of c-myc antisense oligodeoxynucleotides (ASODNs) combined with <jats:sup>188<\/jats:sup>Re radiation therapy on VSMC proliferation in rabbit common iliac arteries injured by the porous balloon catheter to explore the therapeutic potential of the combined therapy for the prevention of restenosis. The iliac arteries in rabbits were injured with balloon catheters, and radiation therapy was carried out with a 2.5\u00a0mm balloon catheter filled with <jats:sup>188<\/jats:sup>Re (8 or 15 Gy), and ASODNs (300\u00a0\u00b5g) were applied to the adventitia introduced using a pluronic gel releasing system and a lipofectin delivery system. After 3 weeks, the animals were killed and defined segments of arteries were sectioned. The histological sections were stained using \u03b1-actin immunohistochemistry staining. The positive \u03b1-actin ratios were calculated and analyzed statistically among groups. In contrast to the rate of \u03b1-actin positive cell staining in the control group, the rate of \u03b1-actin positive cell staining did not decrease (P\u00a0&gt; 0.05) in the <jats:sup>188<\/jats:sup>Re-irradiated group (8 Gy). However, in the ASODN-treated group, the <jats:sup>188<\/jats:sup>Re-irradiated group (15 Gy), and the combined ASODN \u2013 <jats:sup>188<\/jats:sup>Reirradiated groups (8 or 15 Gy), the ratios had markedly decreased (P\u00a0&lt; 0.01). The effect of the combined group (ASODNs + <jats:sup>188<\/jats:sup>Re (15 Gy)) provided the lowest level of \u03b1-actin positive cell staining (P\u00a0&lt; 0.01). The ASODNs (300\u00a0\u00b5g) effectively decreased VSMC poliferation. The effect of the <jats:sup>188<\/jats:sup>Re radiation on the VSMCs depended on the dosage. The ASODNs (300\u00a0\u00b5g) and combined <jats:sup>188<\/jats:sup>Re irradiation effectively lowered VSMC proliferation, and the effect was better than that achieved with any other treatment. <\/jats:p>","DOI":"10.1139\/o06-206","type":"journal-article","created":{"date-parts":[[2007,5,28]],"date-time":"2007-05-28T20:33:50Z","timestamp":1180384430000},"page":"164-168","source":"Crossref","is-referenced-by-count":0,"title":["The effect of locally delivered <i>c-myc<\/i> antisense oligonucleotides combined with intravascular brachytherapy of <sup>188<\/sup>Re liquid-filled balloon therapy on vascular smooth muscle cell proliferation in rabbit iliac arteries after injury with a balloon catheterThis paper is one of a selection of papers in this Special Issue, entitled International Symposium on Recent Advances in Molecular, Clinical, and Social Medicine, and has undergone the Journal's usual peer-review process."],"prefix":"10.1139","volume":"85","author":[{"given":"Wei","family":"Wang","sequence":"first","affiliation":[{"name":"Cardiovascular Department of 1st Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong province 515041, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-lin","family":"Li","sequence":"additional","affiliation":[{"name":"Cardiovascular Department of 1st Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong province 515041, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Cardiovascular Department of 1st Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong province 515041, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"atypb1\/ref1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041500309"},{"key":"atypb2\/ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199812033392304"},{"key":"atypb3\/ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0008-6363(96)00099-5"},{"key":"atypb4\/ref4","doi-asserted-by":"crossref","first-page":"12865","DOI":"10.1016\/S0021-9258(18)67172-8","volume":"261","author":"Kindy M.S.","year":"1986","journal-title":"J. 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(Engl.)"}],"container-title":["Biochemistry and Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdnsciencepub.com\/doi\/full-xml\/10.1139\/o06-206","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdnsciencepub.com\/doi\/pdf\/10.1139\/o06-206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T18:09:17Z","timestamp":1751479757000},"score":1,"resource":{"primary":{"URL":"https:\/\/cdnsciencepub.com\/doi\/10.1139\/o06-206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,4,1]]}},"alternative-id":["10.1139\/o06-206"],"URL":"https:\/\/doi.org\/10.1139\/o06-206","relation":{},"ISSN":["0829-8211","1208-6002"],"issn-type":[{"type":"print","value":"0829-8211"},{"type":"electronic","value":"1208-6002"}],"subject":[],"published":{"date-parts":[[2007,4]]}}}