{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:01:48Z","timestamp":1792008108804,"version":"4.4.0"},"reference-count":46,"publisher":"Canadian Science Publishing","issue":"2","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochem. Cell Biol."],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:p> Treatment of liver fibrosis and cirrhosis remains a challenging field. Hepatocyte injury and the activation of hepatic stellate cells are the 2 major events in the development of liver fibrosis and cirrhosis. It is known that several Chinese herbs have significant beneficial effects on the liver; therefore, the purpose of the present study was to investigate the therapeutic effect of saikosaponin-d (SSd) on liver fibrosis and cirrhosis. A rat model of liver fibrosis was established using the dimethylnitrosamine method. Liver tissue and serum were used to examine the effect of SSd on liver fibrosis. A hepatocyte culture was also used to investigate how SSd can protect hepatocytes from oxidative injury induced by carbon tetrachloride. The results showed that SSd significantly reduced collagen I deposition in the liver and alanine aminotransferase level in the serum. Moreover, SSd decreased the content of TGF-\u03b21 in the liver, which was significantly elevated after dimethylnitrosamine induced liver fibrosis. Furthermore, SSd was able to alleviate hepatocyte injury from oxidative stress. In conclusion, SSd could postpone the development of liver fibrosis by attenuating hepatocyte injury. <\/jats:p>","DOI":"10.1139\/o07-010","type":"journal-article","created":{"date-parts":[[2007,5,28]],"date-time":"2007-05-28T20:33:50Z","timestamp":1180384430000},"page":"189-195","source":"Crossref","is-referenced-by-count":54,"title":["Saikosaponin-d attenuates the development of liver fibrosis by preventing hepatocyte injuryThis paper is one of a selection of papers in this Special Issue, entitled International Symposium on Recent Advances in Molecular, Clinical, and Social Medicine, and has undergone the Journal's usual peer-review process."],"prefix":"10.1139","volume":"85","author":[{"given":"Jianghong","family":"Fan","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, University of Manitoba, 50 Sifton Road, Winnipeg, MB R3T\u00a02N2, Canada."},{"name":"Faculty of Medicine, University of Manitoba, Winnipeg, MB R3E\u00a00W3, Canada."},{"name":"Department of Pharmacology, Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing 100029, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, University of Manitoba, 50 Sifton Road, Winnipeg, MB R3T\u00a02N2, Canada."},{"name":"Faculty of Medicine, University of Manitoba, Winnipeg, MB R3E\u00a00W3, Canada."},{"name":"Department of Pharmacology, Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing 100029, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, University of Manitoba, 50 Sifton Road, Winnipeg, MB R3T\u00a02N2, Canada."},{"name":"Faculty of Medicine, University of Manitoba, Winnipeg, MB R3E\u00a00W3, Canada."},{"name":"Department of Pharmacology, Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing 100029, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, University of Manitoba, 50 Sifton Road, Winnipeg, MB R3T\u00a02N2, Canada."},{"name":"Faculty of Medicine, University of Manitoba, Winnipeg, MB R3E\u00a00W3, Canada."},{"name":"Department of Pharmacology, Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing 100029, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tailing","family":"Wang","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, University of Manitoba, 50 Sifton Road, Winnipeg, MB R3T\u00a02N2, Canada."},{"name":"Faculty of Medicine, University of Manitoba, Winnipeg, MB R3E\u00a00W3, Canada."},{"name":"Department of Pharmacology, Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing 100029, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Shen","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, University of Manitoba, 50 Sifton Road, Winnipeg, MB R3T\u00a02N2, Canada."},{"name":"Faculty of Medicine, University of Manitoba, Winnipeg, MB R3E\u00a00W3, Canada."},{"name":"Department of Pharmacology, Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing 100029, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaw","family":"Siow","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, University of Manitoba, 50 Sifton Road, Winnipeg, MB R3T\u00a02N2, Canada."},{"name":"Faculty of Medicine, University of Manitoba, Winnipeg, MB R3E\u00a00W3, Canada."},{"name":"Department of Pharmacology, Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing 100029, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Choy","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, University of Manitoba, 50 Sifton Road, Winnipeg, MB R3T\u00a02N2, Canada."},{"name":"Faculty of Medicine, University of Manitoba, Winnipeg, MB R3E\u00a00W3, Canada."},{"name":"Department of Pharmacology, Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing 100029, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuewen","family":"Gong","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, University of Manitoba, 50 Sifton Road, Winnipeg, MB R3T\u00a02N2, Canada."},{"name":"Faculty of Medicine, University of Manitoba, Winnipeg, MB R3E\u00a00W3, Canada."},{"name":"Department of Pharmacology, Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing 100029, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"atypb1\/ref1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00510139"},{"key":"atypb2\/ref2","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/j.2042-7158.1985.tb03066.x","volume":"37","author":"Abe H.","year":"1985","journal-title":"J. Pharm. Pharmacol."},{"key":"atypb3\/ref3","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200524282"},{"key":"atypb4\/ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(03)00058-1"},{"key":"atypb5\/ref5","doi-asserted-by":"crossref","first-page":"e214","DOI":"10.2741\/beljaars","volume":"7","author":"Beljaars L.","year":"2002","journal-title":"Front. Biosci."},{"key":"atypb6\/ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(73)90138-X"},{"key":"atypb7\/ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(98)00376-2"},{"key":"atypb8\/ref8","first-page":"350","volume":"20","author":"Bu S.","year":"2000","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"atypb9\/ref9","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1093\/alcalc\/agh065","volume":"39","author":"Castilla R.","year":"2004","journal-title":"Alcohol Alcohol."},{"key":"atypb10\/ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.09.040"},{"key":"atypb11\/ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(97)00836-9"},{"key":"atypb12\/ref12","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(95)11933-N"},{"key":"atypb13\/ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-005-1055-4"},{"key":"atypb14\/ref14","doi-asserted-by":"publisher","DOI":"10.1191\/0960327105ht548oa"},{"key":"atypb15\/ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(00)00352-8"},{"key":"atypb16\/ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2005.12.010"},{"key":"atypb17\/ref17","first-page":"S39","volume":"54","author":"Gressner A.M.","year":"1996","journal-title":"Kidney Int. Suppl."},{"key":"atypb18\/ref18","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.099499"},{"key":"atypb19\/ref19","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M310284200"},{"key":"atypb20\/ref20","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1248\/bpb1978.9.189","volume":"9","author":"Iwama H.","year":"1986","journal-title":"J. Pharmacobiodyn."},{"key":"atypb21\/ref21","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.1994.1291"},{"key":"atypb22\/ref22","doi-asserted-by":"publisher","DOI":"10.1016\/0162-3109(95)00059-3"},{"key":"atypb23\/ref23","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S1665-2681(19)32127-1","volume":"2","author":"Kershenobich Stalnikowitz D.","year":"2003","journal-title":"Ann. Hepatol."},{"key":"atypb24\/ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2005.01.016"},{"key":"atypb25\/ref25","first-page":"III","volume":"161","author":"Kmiec Z.","year":"2001","journal-title":"Adv. Anat. Embryol. Cell Biol."},{"key":"atypb26\/ref26","doi-asserted-by":"publisher","DOI":"10.1007\/BF01958074"},{"key":"atypb27\/ref27","doi-asserted-by":"publisher","DOI":"10.1211\/0022357001773896"},{"key":"atypb28\/ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2003.12.002"},{"key":"atypb29\/ref29","doi-asserted-by":"publisher","DOI":"10.1159\/000087437"},{"key":"atypb30\/ref30","first-page":"446","volume":"18","author":"Liang Y.","year":"1998","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"atypb31\/ref31","doi-asserted-by":"publisher","DOI":"10.1021\/js9701014"},{"key":"atypb32\/ref32","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(03)00444-1"},{"key":"atypb33\/ref33","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1248\/cpb.37.2736","volume":"37","author":"Nose M.","year":"1989","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"key":"atypb34\/ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2005.02.051"},{"key":"atypb35\/ref35","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.25.1451"},{"key":"atypb36\/ref36","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-17554"},{"key":"atypb37\/ref37","doi-asserted-by":"publisher","DOI":"10.1002\/jat.2550070402"},{"key":"atypb38\/ref38","first-page":"27","volume":"4","author":"Safadi R.","year":"2002","journal-title":"MedGenMed."},{"key":"atypb39\/ref39","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(91)90084-O"},{"key":"atypb40\/ref40","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.1062"},{"key":"atypb41\/ref41","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2000.02138.x"},{"key":"atypb42\/ref42","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/0192-0561(91)90068-I","volume":"13","author":"Ushio Y.","year":"1991","journal-title":"Int. J. Immunopharmacol."},{"key":"atypb43\/ref43","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/0192-0561(91)90069-J","volume":"13","author":"Ushio Y.","year":"1991","journal-title":"Int. J. Immunopharmacol."},{"key":"atypb44\/ref44","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1093\/clinchem\/39.12.2522","volume":"39","author":"Wasowicz W.","year":"1993","journal-title":"Clin. Chem."},{"key":"atypb45\/ref45","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510240328"},{"key":"atypb46\/ref46","doi-asserted-by":"publisher","DOI":"10.1023\/B:GLYC.0000004014.89506.22"}],"container-title":["Biochemistry and Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdnsciencepub.com\/doi\/full-xml\/10.1139\/O07-010","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdnsciencepub.com\/doi\/pdf\/10.1139\/O07-010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T18:09:28Z","timestamp":1751479768000},"score":1,"resource":{"primary":{"URL":"https:\/\/cdnsciencepub.com\/doi\/10.1139\/O07-010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,4,1]]}},"alternative-id":["10.1139\/O07-010"],"URL":"https:\/\/doi.org\/10.1139\/o07-010","relation":{},"ISSN":["0829-8211","1208-6002"],"issn-type":[{"value":"0829-8211","type":"print"},{"value":"1208-6002","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4]]}}}