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The chemical scaffold of the tetracyclines is a versatile and modifiable structure that is able to interact with many cellular targets. The recent availability of detailed molecular interactions between tetracycline and its cellular targets, along with an understanding of the tetracycline biosynthetic pathway, has provided us with a unique opportunity to usher in a new era of rational drug design. Herein we discuss recent findings that have clarified the mode of action and the biosynthetic pathway of tetracyclines and that have shed light on the chemical biology of tetracycline antibiotics. <\/jats:p>","DOI":"10.1139\/o08-002","type":"journal-article","created":{"date-parts":[[2008,4,11]],"date-time":"2008-04-11T15:35:08Z","timestamp":1207928108000},"page":"124-136","source":"Crossref","is-referenced-by-count":92,"title":["Chemical biology of tetracycline antibioticsThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB \u2014 Systems and Chemical Biology, and has undergone the Journal's usual peer review process."],"prefix":"10.1139","volume":"86","author":[{"given":"Bijan","family":"Zakeri","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Biomedical Sciences, DeGroote School of Medicine, McMaster University, 1200 Main St. W, Hamilton, ON L8N\u00a03Z5, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard D.","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biomedical Sciences, DeGroote School of Medicine, McMaster University, 1200 Main St. W, Hamilton, ON L8N\u00a03Z5, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"atypb1\/ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2004.04.002"},{"key":"atypb2\/ref2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl224"},{"key":"atypb3\/ref3","doi-asserted-by":"publisher","DOI":"10.2174\/1568005023342506"},{"key":"atypb4\/ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(80)80247-6"},{"key":"atypb5\/ref5","first-page":"186","volume":"55","author":"Baltz R.H.","year":"2005","journal-title":"SIM News"},{"key":"atypb6\/ref6","doi-asserted-by":"publisher","DOI":"10.1007\/BF02141995"},{"key":"atypb7\/ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00216-6"},{"key":"atypb8\/ref8","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.1016\/S0021-9258(18)49928-0","volume":"266","author":"Burdett V.","year":"1991","journal-title":"J. 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