{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:48:09Z","timestamp":1761518889031,"version":"3.41.0"},"reference-count":33,"publisher":"Canadian Science Publishing","issue":"5","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochem. Cell Biol."],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:p> Pathological angiogenesis in the eye is the most common cause of blindness in all age groups. In physiological and pathological cellular processes including angiogenesis, ion homeostasis is greatly affected. This study is to investigate the role of calcium ion in physiological and pathological angiogenesis in the retina, which is based on the results of ion mapping by time-of-flight secondary ion mass spectrometry (TOF-SIMS). We provided that calcium distribution is the most accordant to change with physiological vessel formation of development in the retina and pathological angiogenesis of oxygen-induced retinopathy (OIR), which is supported by ion mapping in retinal tissue using TOF-SIMS. In addition to anti-proliferative and anti-angiogenic activity of the calcium inhibitor on endothelial cells, retinal neovascularization of OIR was effectively inhibited by the calcium inhibitor. Calcium ion could play a crucial role in physiological and pathological angiogenesis in the retina. Moreover, TOF-SIMS could be a good method to simultaneously evaluate the changes of variable ions of the retina in biological processes. <\/jats:p>","DOI":"10.1139\/o08-125","type":"journal-article","created":{"date-parts":[[2008,10,10]],"date-time":"2008-10-10T18:42:26Z","timestamp":1223664146000},"page":"459-467","source":"Crossref","is-referenced-by-count":6,"title":["In situ calcium mapping in the mouse retina via time-of-flight secondary ion mass spectrometry: modulation of retinal angiogenesis by calcium ion in development and oxygen-induced retinopathy"],"prefix":"10.1139","volume":"86","author":[{"given":"Jeong Hun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Seoul National University College of Medicine & Seoul Artificial Eye Center, Clinical Research Institute, Seoul National University Hospital, Seoul 151-744, Korea."},{"name":"Department of Radiology, College of Medicine, Soonchunhyang University, Korea."},{"name":"NanoBio Fusion Research Center, Korea Research Institute of Standards and Science (KRISS), Korea."},{"name":"NeuroVascular Coordination Research Center, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Hyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul National University College of Medicine & Seoul Artificial Eye Center, Clinical Research Institute, Seoul National University Hospital, Seoul 151-744, Korea."},{"name":"Department of Radiology, College of Medicine, Soonchunhyang University, Korea."},{"name":"NanoBio Fusion Research Center, Korea Research Institute of Standards and Science (KRISS), Korea."},{"name":"NeuroVascular Coordination Research Center, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Suk","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul National University College of Medicine & Seoul Artificial Eye Center, Clinical Research Institute, Seoul National University Hospital, Seoul 151-744, Korea."},{"name":"Department of Radiology, College of Medicine, Soonchunhyang University, Korea."},{"name":"NanoBio Fusion Research Center, Korea Research Institute of Standards and Science (KRISS), Korea."},{"name":"NeuroVascular Coordination Research Center, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Hun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul National University College of Medicine & Seoul Artificial Eye Center, Clinical Research Institute, Seoul National University Hospital, Seoul 151-744, Korea."},{"name":"Department of Radiology, College of Medicine, Soonchunhyang University, Korea."},{"name":"NanoBio Fusion Research Center, Korea Research Institute of Standards and Science (KRISS), Korea."},{"name":"NeuroVascular Coordination Research Center, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Geol","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul National University College of Medicine & Seoul Artificial Eye Center, Clinical Research Institute, Seoul National University Hospital, Seoul 151-744, Korea."},{"name":"Department of Radiology, College of Medicine, Soonchunhyang University, Korea."},{"name":"NanoBio Fusion Research Center, Korea Research Institute of Standards and Science (KRISS), Korea."},{"name":"NeuroVascular Coordination Research Center, College of Pharmacy and 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