{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T06:03:38Z","timestamp":1770789818060,"version":"3.50.0"},"reference-count":16,"publisher":"Canadian Science Publishing","issue":"4","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochem. Cell Biol."],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:p> Cleft lip and cleft palate are common congenital craniofacial birth defects in humans. Phenytoin (PHT) is a risk factor of cleft palate formation; however, the molecular mechanisms by which phenytoin exerts its teratogenic effects resulting in cleft palate remain unknown. The Satb2 gene mutation is associated with cleft palate. Satb2-deficient mice exhibit cleft palate deformity and an up-regulation of Hoxa2 in the fronto-nasal region. In this study, phenytoin was administered intraperitoneally to pregnant C57BL\/6 mice on the 10th day of gestation. Real-time PCR results showed that the expressions of Satb2 and Hoxa2 in craniofacial tissues of mouse embryos were obviously different at different time points. The Satb2 gene was down-regulated and the Hoxa2 gene was up-regulated in phenytoin-treated mouse embryonic craniofacial tissue. We conclude that phenytoin may regulate the expression of these two genes in C57BL\/6 mice and it may also be involved in the formation of cleft palate. <\/jats:p>","DOI":"10.1139\/o10-013","type":"journal-article","created":{"date-parts":[[2010,7,22]],"date-time":"2010-07-22T19:28:05Z","timestamp":1279826885000},"page":"731-735","source":"Crossref","is-referenced-by-count":12,"title":["Effects of phenytoin on <i>Satb2<\/i> and <i>Hoxa2<\/i> gene expressions in mouse embryonic craniofacial tissueThis paper is one of a selection of papers published in this special issue entitled \u201cSecond International Symposium on Recent Advances in Basic, Clinical, and Social Medicine\u201d and has undergone the Journal's usual peer review process."],"prefix":"10.1139","volume":"88","author":[{"given":"Xiao Yan","family":"Mao","sequence":"first","affiliation":[{"name":"Cleft Lip and Palate Treatment Center, the Second Affiliated Hospital of Shantou University Medical College, Dongxia Rd., Shantou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi Jie","family":"Tang","sequence":"additional","affiliation":[{"name":"Cleft Lip and Palate Treatment Center, the Second Affiliated Hospital of Shantou University Medical College, Dongxia Rd., Shantou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"rg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1038\/ng730"},{"key":"rg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1086\/508214"},{"key":"rg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.05.012"},{"key":"rg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2004.08.036"},{"key":"rg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1126\/science.7455686"},{"key":"rg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg248"},{"key":"rg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1111011"},{"key":"rg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(199707)209:3<255::AID-AJA1>3.0.CO;2-H"},{"key":"atypb1\/ref999","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1242\/dev.125.14.2587","volume":"125","author":"Kanzler B.","year":"1998","journal-title":"Development,"},{"key":"rg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1017\/S0016672300026719"},{"key":"rg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420370314"},{"key":"rg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420330109"},{"key":"rg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007006024407"},{"key":"rg13\/ref13","doi-asserted-by":"publisher","DOI":"10.1038\/ng0494-348"},{"key":"rg14\/ref14","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(96)00340-1"},{"key":"rg15\/ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(98)00193-2"}],"container-title":["Biochemistry and Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdnsciencepub.com\/doi\/full-xml\/10.1139\/O10-013","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdnsciencepub.com\/doi\/pdf\/10.1139\/O10-013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T17:57:31Z","timestamp":1751479051000},"score":1,"resource":{"primary":{"URL":"https:\/\/cdnsciencepub.com\/doi\/10.1139\/O10-013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,8,1]]}},"alternative-id":["10.1139\/O10-013"],"URL":"https:\/\/doi.org\/10.1139\/o10-013","relation":{},"ISSN":["0829-8211","1208-6002"],"issn-type":[{"value":"0829-8211","type":"print"},{"value":"1208-6002","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8]]}}}