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To demonstrate the current knowledge of the role of such proteins, we have focused our attention on the methylated DNA binding and chromatin-associated protein MeCP2. Structural studies using chromatin assembled in vitro have revealed that MeCP2 can associate with nucleosomes in an N-terminus dependent manner and efficiently condense nucleosome arrays. The present review attempts to match MeCP2 structural domains, or lack thereof, and specific chromatin features needed for the proper recruitment of MeCP2 to its multiple functions as either activator or repressor. We specifically focused on MeCP2\u2019s role in Rett syndrome, a neurological disorder associated with specific MeCP2 mutations. <\/jats:p>","DOI":"10.1139\/o10-112","type":"journal-article","created":{"date-parts":[[2011,2,15]],"date-time":"2011-02-15T23:32:07Z","timestamp":1297812727000},"page":"1-11","source":"Crossref","is-referenced-by-count":88,"title":["MeCP2: structure and functionThis paper is one of a selection of papers published in a Special Issue entitled 31st Annual International Asilomar Chromatin and Chromosomes Conference, and has undergone the Journal\u2019s usual peer review process."],"prefix":"10.1139","volume":"89","author":[{"given":"Nicholas L.","family":"Adkins","sequence":"first","affiliation":[{"name":"Byrd Biotechnology Building, Department of Biological Sciences, Marshall University, 1 John Marshall Drive, Huntington, WV 25755, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe T.","family":"Georgel","sequence":"additional","affiliation":[{"name":"Byrd Biotechnology Building, Department of Biological Sciences, Marshall University, 1 John Marshall Drive, Huntington, WV 25755, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"rg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M700855200"},{"key":"rg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1038\/380646a0"},{"key":"rg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1038\/13810"},{"key":"rg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M203009200"},{"key":"rg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1021\/bi0001271"},{"key":"rg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg604"},{"key":"rg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1038\/35013100"},{"key":"atypb1\/ref91","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/0006-3002(59)90649-3","volume":"32","author":"Benson E.E.","year":"1959","journal-title":"Biochim. 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