{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T14:15:21Z","timestamp":1781187321080,"version":"3.54.1"},"reference-count":56,"publisher":"Canadian Science Publishing","issue":"3","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochem. Cell Biol."],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p> Entamoeba histolytica is the causative agent of amoebiasis, a disease that produces dysentery as a result of the perforation of the large intestine. This parasite often invades other organs, primarily the liver, leading to an amoebic liver abscess (ALA), which can cause death. Metronidazole is the drug of choice for the treatment of ALA; however, it produces toxic side effects in patients. Lactoferrin (Lf) is a glycoprotein of the innate immune response that sequesters iron in the mucosae. Lf possesses immune-regulatory properties, such as antiinflammatory and antioxidant activities. Moreover, the microbicidal activity of apoLf, which lacks bound iron, has been shown. In this study, we evaluated the therapeutic effect of bovine Lf (bLf) against ALA in a model of hepatic amoebiasis in hamsters. Interestingly, hamsters treated intragastrically with Lf (2.5\u00a0mg\/100\u00a0g mass) over a period of 8\u00a0days showed no clinical signs of disease and ALA was effectively decreased, with only 0.63% detectable lesion, compared with 63% in untreated animals. Furthermore, liver function and blood cells approached normal levels among those receiving bLf treatment. These results suggest that bLf may aid in the therapy of amoebiasis, likely without producing undesirable effects in patients. <\/jats:p>","DOI":"10.1139\/o11-084","type":"journal-article","created":{"date-parts":[[2012,5,16]],"date-time":"2012-05-16T17:27:29Z","timestamp":1337189249000},"page":"425-434","source":"Crossref","is-referenced-by-count":18,"title":["Effect of bovine lactoferrin in a therapeutic hamster model of hepatic amoebiasis<sup>1<\/sup>This article is part of a Special Issue entitled Lactoferrin and has undergone the Journal's usual peer review process."],"prefix":"10.1139","volume":"90","author":[{"given":"Cynthia","family":"Ordaz-Pichardo","sequence":"first","affiliation":[{"name":"Laboratorio de Biolog\u00eda Celular y Productos Naturales, Escuela Nacional de Medicina y Homeopat\u00eda, Instituto Polit\u00e9cnico Nacional, Guillermo Massieu Helguera No.\u00a0239 Fraccionamiento La Escalera, Ticom\u00e1n, D.F. 07320, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidia","family":"Le\u00f3n-Sicairos","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n de la Facultad de Medicina, Universidad Aut\u00f3noma de Sinaloa. 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