{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T03:11:44Z","timestamp":1767064304206,"version":"3.41.0"},"reference-count":37,"publisher":"Canadian Science Publishing","issue":"3","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochem. Cell Biol."],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p> Mice orally infected with enterohaemorrhagic Escherichia coli (EHEC) O157:H7 were used to evaluate the activity of bovine lactoferrin (bLF) and the synthetic peptide LFchimera. Groups of BALB\/c mice inoculated intragastrically with EHEC O157:H7 showed chronic intestinal infection with the pathogen that persisted over 6\u00a0days and resulted in a high mortality rate (90%). LFchimera and kanamycin significantly decreased (40%) this mortality rate (P = 0.028). On the other hand, although mice administered with bLF showed an important reduction in mortality (50%), this was not statistically significant (P = 0.070). In infected and untreated mice, severe tubular necrosis, glomerular lesions, and moderate intratubular hyaline casts were found in the kidney. However, in the bLF and LFchimera groups we found a reduction in the damage and a substantial decrease in the bacterial concentration excreted in feces 48\u00a0h after infection. Furthermore, sepsis caused by EHEC was reduced by the treatments, evidenced by the fact that bacteria were not detected in the kidney or liver 72\u00a0h after infection. The results suggest the bLF and LFchimera could have potential as therapeutics in EHEC infections. <\/jats:p>","DOI":"10.1139\/o11-089","type":"journal-article","created":{"date-parts":[[2012,5,16]],"date-time":"2012-05-16T17:27:29Z","timestamp":1337189249000},"page":"405-411","source":"Crossref","is-referenced-by-count":23,"title":["Protective effects of lactoferrin chimera and bovine lactoferrin in a mouse model of enterohaemorrhagic <i>Escherichia coli<\/i> O157:H7 infection<sup>1<\/sup>This article is part of a Special Issue entitled Lactoferrin and has undergone the Journal's usual peer review process."],"prefix":"10.1139","volume":"90","author":[{"given":"H\u00e9ctor","family":"Flores-Villase\u00f1or","sequence":"first","affiliation":[{"name":"Programa Regional para el Doctorado en Biotecnolog\u00eda. Facultad de Ciencias Qu\u00edmico-Biol\u00f3gicas. Universidad Aut\u00f3noma de Sinaloa. 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