{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:08:08Z","timestamp":1790903288073,"version":"4.1.0"},"reference-count":58,"publisher":"Canadian Science Publishing","issue":"4","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochem. Cell Biol."],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p> We hypothesized that vitamin A (VA) status may affect obesity development. Male Zucker lean (ZL) and fatty (ZF) rats after weaning were fed a synthetic VA deficient (VAD) or VA sufficient (VAS) diet for 8 weeks before their plasma parameters and hepatic genes\u2019 expression were analyzed. The body mass (BM) of ZL or ZF rats fed the VAD diet was lower than that of their corresponding controls fed the VAS diet at 5 or 2 weeks, respectively. The VAD ZL and ZF rats had less food intake than the VAS rats after 5 weeks. The VAD ZL and ZF rats had lower plasma glucose, triglyceride, insulin, and leptin levels, as well as lower liver glycogen content, net mass of epididymal fat, and liver\/BM and epididymal fat\/BM ratios (ZL only) than their respective VAS controls. VAD rats had lower hepatic Cyp26a1, Srebp-1c, Fas, Scd1, Me1, Gck, and Pklr (ZL and ZF); and higher Igfbp1 (ZL and ZF), Pck1(ZF only), and G6pc (ZF only) mRNA levels than their respective VAS controls. We conclude that ZL and ZF rats responded differently to dietary VA deficiency. VA status affected obesity development and altered the expression of hepatic genes for fuel metabolism in ZF rats. The mechanisms will help us to combat metabolic diseases. <\/jats:p>","DOI":"10.1139\/o2012-012","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T14:05:54Z","timestamp":1340892354000},"page":"548-557","source":"Crossref","is-referenced-by-count":43,"title":["Vitamin A status affects obesity development and hepatic expression of key genes for fuel metabolism in Zucker fatty rats"],"prefix":"10.1139","volume":"90","author":[{"given":"Yan","family":"Zhang","sequence":"first","affiliation":[{"name":"The Diabetes Center at Wuhan Central Hospital, No.\u00a026 Shengli Road, Jiangan District, Wuhan, Hubei 430014, China."},{"name":"Department of Nutrition, University of Tennessee at Knoxville, 229 Jessie Harris Building, 1215 West Cumberland Avenue, Knoxville, TN 37996, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nutrition, University of Tennessee at Knoxville, 229 Jessie Harris Building, 1215 West Cumberland Avenue, Knoxville, TN 37996, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nutrition, University of Tennessee at Knoxville, 229 Jessie Harris Building, 1215 West Cumberland Avenue, Knoxville, TN 37996, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nutrition, University of Tennessee at Knoxville, 229 Jessie Harris Building, 1215 West Cumberland Avenue, Knoxville, TN 37996, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Diabetes Center at Wuhan Central Hospital, No.\u00a026 Shengli Road, Jiangan District, Wuhan, Hubei 430014, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoxun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nutrition, University of Tennessee at Knoxville, 229 Jessie Harris Building, 1215 West Cumberland Avenue, Knoxville, TN 37996, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114509990729"},{"issue":"4","key":"refg2\/ref2","doi-asserted-by":"crossref","first-page":"E685","DOI":"10.1152\/ajpendo.00253.2003","volume":"285","author":"Barthel A.","year":"2003","journal-title":"Am. 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