{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T05:31:34Z","timestamp":1739511094477,"version":"3.37.0"},"reference-count":22,"publisher":"Canadian Science Publishing","issue":"2","license":[{"start":{"date-parts":[[1961,2,1]],"date-time":"1961-02-01T00:00:00Z","timestamp":-281318400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Biochem. Physiol."],"published-print":{"date-parts":[[1961,2,1]]},"abstract":"<jats:p>A modification of a colorimetric method for the determination of carbonic anhydrase is described in which substrate is supplied in the form of gaseous carbon dioxide. Using this method, the inhibitory effects of seven carbonic anhydrase inhibitors used in the control of intraocular pressure were investigated. It was found that equilibrium between enzyme and inhibitor required from 2 minutes to 64 minutes to become established. A comparison of the inhibitory potencies of the various drugs is presented.<\/jats:p>","DOI":"10.1139\/o61-027","type":"journal-article","created":{"date-parts":[[2009,12,17]],"date-time":"2009-12-17T16:54:15Z","timestamp":1261068855000},"page":"287-295","source":"Crossref","is-referenced-by-count":9,"title":["A COMPARATIVE STUDY OF SOME CARBONIC ANHYDRASE INHIBITORS"],"prefix":"10.1139","volume":"39","author":[{"given":"V. R.","family":"Woodford","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nel","family":"Leegwater","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. M.","family":"Drance","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"p_1\/p_1_1","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1001\/archopht.1953.00920030409001","volume":"50","author":"KINSEY A.M.","year":"1953","journal-title":"Arch. Ophthalrnol."},{"key":"p_2\/p_2_1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1748-1716.1951.tb00833.x","volume":"24","author":"WISTRAND.","year":"1952","journal-title":"Acta Physiol. Scand."},{"key":"p_3\/p_3_1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1001\/archopht.1955.00930010465001","volume":"53","author":"GREEN C.A.","year":"1955","journal-title":"Arch. Ophthalmol."},{"key":"p_4\/p_4_1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/0002-9394(55)91849-3","volume":"40","author":"BALLINTINE T. H.","year":"1955","journal-title":"MAREN. Am. J. Ophthalmol."},{"key":"p_5\/p_5_1","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/146164a0","volume":"146","author":"MANN D.","year":"1940","journal-title":"KEILIN. Nature"},{"key":"p_6\/p_6_1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1126\/science.93.2403.66","volume":"93","author":"LOCKE E.R.","year":"1941","journal-title":"MELLON.Science"},{"key":"p_7\/p_7_1","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0021-9258(19)51331-X","volume":"158","author":"DAVENPORT.","year":"1945","journal-title":"J. Biol. Chem."},{"key":"p_8\/p_8_1","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1042\/bj0430525","volume":"43","author":"KREBS.","year":"1948","journal-title":"Biochem. J."},{"key":"p_9\/p_9_1","doi-asserted-by":"crossref","first-page":"4890","DOI":"10.1021\/ja01167a011","volume":"72","author":"ROBLIN J. W.","year":"1950","journal-title":"J. Am. Chem. Soc."},{"key":"p_10\/p_10_1","doi-asserted-by":"crossref","first-page":"4893","DOI":"10.1021\/ja01167a012","volume":"72","author":"MILLER A. M.","year":"1950","journal-title":"ROBLIN. J. Am. Chem. Soc."},{"key":"p_12\/p_12_1","first-page":"696","volume":"10","author":"BEASLEY B. G.","year":"1958","journal-title":"Pharmacol."},{"key":"p_13\/p_13_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0002-9394(54)92027-9","volume":"37","author":"B.","year":"1954","journal-title":"BECKER. Am. J. Ophthalmol."},{"key":"p_14\/p_14_1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1001\/archopht.1955.00930020327001","volume":"54","author":"BECKER M. A.","year":"1955","journal-title":"Arch. Ophthalmol."},{"key":"p_15\/p_15_1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0002-9394(55)91845-6","volume":"40","author":"B.","year":"1955","journal-title":"BECKER. Am. J. Ophthalmol."},{"key":"p_16\/p_16_1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1113\/jphysiol.1933.sp003077","volume":"80","author":"MELDRUM F. J.","journal-title":"ROUGHTON. J. Physiol."},{"key":"p_17\/p_17_1","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1042\/bj0302191","volume":"30","author":"PHILPOT J.","year":"1936","journal-title":"Biochem. J."},{"key":"p_18\/p_18_1","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0021-9258(18)75831-6","volume":"103","author":"STADIE H.","year":"1933","journal-title":"BRIEN. J. Biol. Chem."},{"key":"p_19\/p_19_1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0021-9258(18)51011-5","volume":"176","author":"WILBUR N. G.","year":"1948","journal-title":"ANDERSON. J. Biol. Chem."},{"key":"p_20\/p_20_1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0022-3565(25)11604-2","volume":"115","author":"MILLICHAP D. M.","year":"1955","journal-title":"GOODMAN. J. Pharmacol. Exptl. Therap."},{"key":"p_21\/p_21_1","first-page":"244","volume":"95","author":"MAREN V. I.","year":"1954","journal-title":"JR. Bull. Johns Hopkins Hosp."},{"key":"p_22\/p_22_1","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/0006-3002(60)90156-6","volume":"39","author":"LINDSKOG","year":"1960","journal-title":"Biophys. Acta"},{"key":"p_23\/p_23_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0002-9394(14)78070-5","volume":"46","author":"M.","year":"1958","journal-title":"GORDON. Am. J. Ophthalmol."}],"container-title":["Canadian Journal of Biochemistry and Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/o61-027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T22:08:29Z","timestamp":1739484509000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/o61-027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1961,2,1]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1961,2,1]]}},"alternative-id":["10.1139\/o61-027"],"URL":"https:\/\/doi.org\/10.1139\/o61-027","relation":{},"ISSN":["0576-5544"],"issn-type":[{"type":"print","value":"0576-5544"}],"subject":[],"published":{"date-parts":[[1961,2,1]]}}}