{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:40:04Z","timestamp":1760888404186},"reference-count":7,"publisher":"Canadian Science Publishing","issue":"8","license":[{"start":{"date-parts":[[1964,8,1]],"date-time":"1964-08-01T00:00:00Z","timestamp":-170985600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Biochem."],"published-print":{"date-parts":[[1964,8,1]]},"abstract":"<jats:p> Physiological disturbances common to B<jats:sub>6<\/jats:sub> avitaminosis were clearly manifested when 3-day-old chicks were fed a pyridoxine-deficient diet for 8 days. Body and liver weights were depressed but were restored to quasi-normal states after 4 days of pyridoxine supplementation (3\u2002mg\/lb diet). The elevated serum cholesterol levels observed were the result of a failure of this parameter to fall at the rate characteristic of a well-fed bird and not to a specific elevation of the serum cholesterol above the starting conditions. Liver cholesterol levels were unaffected by the hypovitaminosis. Pyridoxine supplementation rapidly re-established normal serum cholesterol levels.The significant depression of C<jats:sup>14<\/jats:sup>-acetate incorporation into liver and serum cholesterol of 7-day-old pyridoxine-deficient chicks was maintained for the next 8 days. Mevalonate-2-C<jats:sup>14<\/jats:sup> incorporation into liver cholesterol was not significantly depressed by the hypovitaminosis at any time during the study. Unlike the controls, mevalonate-2-C<jats:sup>14<\/jats:sup> incorporation into serum cholesterol was significantly lowered in the 11-day-old pyridoxine-deficient chicks, but not at any other time during the study.The significance of these findings and the possible relationship between these factors are discussed. <\/jats:p>","DOI":"10.1139\/o64-125","type":"journal-article","created":{"date-parts":[[2009,12,17]],"date-time":"2009-12-17T21:48:33Z","timestamp":1261086513000},"page":"1161-1168","source":"Crossref","is-referenced-by-count":5,"title":["PYRIDOXINE DEFICIENCY AND CHOLESTEROGENESIS IN THE CHICK"],"prefix":"10.1139","volume":"42","author":[{"given":"P. J.","family":"Lupien","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. B.","family":"Migicovsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"p_1\/p_1_1","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1021\/ja01124a033","volume":"74","author":"IETZI E. E.","year":"1952","journal-title":"Chem. Soc."},{"key":"p_2\/p_2_1","first-page":"385","volume":"74","author":"II E:K","journal-title":"TEKSON. J. Am. Chem. Soc."},{"key":"p_4\/p_4_1","first-page":"226","volume":"41","author":"IVITTEIG R. T.","year":"1952","journal-title":"HOLIIAN. Arch. Hiochem. Biophjs."},{"key":"p_5\/p_5_1","first-page":"67","volume":"44","author":"KKISTEXSEI","year":"1958","journal-title":"Scdnd."},{"key":"p_9\/p_9_1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/jn\/72.1.81","volume":"72","author":"SHAH P. V.","journal-title":"J. Nutr."},{"key":"p_12\/p_12_1","first-page":"179","volume":"42","author":"LUI'IIIN B. B.","year":"1964","journal-title":"Can. J. Biochenl."},{"key":"p_16\/p_16_1","first-page":"l","volume":"144","author":"AT R.","year":"1958","journal-title":"J. Physiol."}],"container-title":["Canadian Journal of Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/o64-125","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T23:55:38Z","timestamp":1578268538000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/o64-125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1964,8,1]]},"references-count":7,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1964,8,1]]}},"alternative-id":["10.1139\/o64-125"],"URL":"https:\/\/doi.org\/10.1139\/o64-125","relation":{},"ISSN":["0008-4018"],"issn-type":[{"value":"0008-4018","type":"print"}],"subject":[],"published":{"date-parts":[[1964,8,1]]}}}