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The hepatic cholesterol esters are greatest at low doses of CCl<jats:sub>4<\/jats:sub>, while the hepatic triglycerides and serum transaminase levels continue to rise as increasing amounts of CCl<jats:sub>4<\/jats:sub>are administered. The amount of liver triglycerides is significantly increased within 2 hours after CCl<jats:sub>4<\/jats:sub>administration, while the hepatic cholesterol ester level and serum transaminase activity are not elevated until 6 hours. An increase in the rate of incorporation of intravenously administered acetate-1-C<jats:sup>14<\/jats:sup>into hepatic triglycerides occurred within 3 hours after CCl<jats:sub>4<\/jats:sub>treatment, but no increase was noted in cholesterol and cholesterol ester radioactivity until an additional 3 hours had elapsed.The treatment of CCl<jats:sub>4<\/jats:sub>-intoxicated rats with phenoxybenzamine, although decreasing necrosis, does not prevent the accumulation of hepatic lipids.Slices of liver from CCl<jats:sub>4<\/jats:sub>-intoxicated animals incorporate acetate-1-C<jats:sup>14<\/jats:sup>more rapidly into cholesterol esters and less rapidly into cholesterol and triglycerides than liver slices from control animals. The presence of CCl<jats:sub>4<\/jats:sub>in the atmosphere above the liver slices from untreated animals induced an increase in acetate-1-C<jats:sup>14<\/jats:sup>incorporation into both cholesterol esters and free fatty acids and a decrease in incorporation into cholesterol. The incorporation of radioactivity into triglycerides was not affected.<\/jats:p>","DOI":"10.1139\/o64-136","type":"journal-article","created":{"date-parts":[[2009,12,17]],"date-time":"2009-12-17T21:48:37Z","timestamp":1261086517000},"page":"1263-1273","source":"Crossref","is-referenced-by-count":7,"title":["THE EFFECT OF CARBON TETRACHLORIDE ON HEPATIC LIPID METABOLISM"],"prefix":"10.1139","volume":"42","author":[{"given":"Bernard","family":"Rubenstein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Rubinstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"p_1\/p_1_1","first-page":"1017","volume":"18","author":"BKODY.","year":"1959","journal-title":"Federation Proc."},{"key":"p_2\/p_2_1","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1152\/ajplegacy.1960.198.3.669","volume":"198","author":"CALVERT T. 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