{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T16:16:01Z","timestamp":1760890561950},"reference-count":21,"publisher":"Canadian Science Publishing","issue":"5","license":[{"start":{"date-parts":[[1966,5,1]],"date-time":"1966-05-01T00:00:00Z","timestamp":-115862400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Biochem."],"published-print":{"date-parts":[[1966,5,1]]},"abstract":"<jats:p> The influence of B<jats:sub>6<\/jats:sub> avitaminosis and the feeding of cholesterol on protein-bound iodine (PBI) of plasma and plasma glutamic\u2013oxalacetic transaminase (PGOT) levels of chicks was studied, and the findings related to relative rates of <jats:sup>14<\/jats:sup>C-acetate incorporation into plasma and liver cholesterol of chicks 3, 5, 11, and 15 days old.High plasma cholesterol levels were noted in the 11-day-old vitamin B<jats:sub>6<\/jats:sub>-deficient chicks. Liver cholesterol levels of this group were not significantly altered. Dietary cholesterol added at a level of 1% significantly increased liver and plasma cholesterol levels of the cholesterol-fed control and vitamin B<jats:sub>6<\/jats:sub>-deficient chicks; it also inhibited <jats:sup>14<\/jats:sup>C-acetate incorporation into plasma and liver cholesterol to a much greater extent than did simple B<jats:sub>6<\/jats:sub> avitaminosis or exogenous cholesterol per se. PBI parameters for control and vitamin B<jats:sub>6<\/jats:sub>-deficient chicks resembled those of plasma and liver cholesterol specific activity curves during the experimental period. Decreased PBI levels were noted 8 days after the beginning of the experiment in the vitamin B<jats:sub>6<\/jats:sub>-deficient birds. Dietary cholesterol significantly decreased PBI levels of 11-day-old control birds but increased it markedly 4 days later. PBI levels of the 11-day-old cholesterol-fed birds deficient in vitamin B<jats:sub>6<\/jats:sub> were not changed, but were significantly increased 4 days later. PGOT levels were highest in 3-day-old control birds, and decreased rapidly thereafter. PGOT levels of the vitamin B<jats:sub>6<\/jats:sub>-deficient chicks were significantly decreased 3 to 4 days after the beginning of the experiment. The supplementary dietary cholesterol increased PGOT levels of 15-day-old cholesterol-fed control birds, but decreased PGOT levels of cholesterol-fed chicks deficient in vitamin B<jats:sub>6<\/jats:sub>. Although preliminary, these observations suggest an interrelationship between pyridoxine, thyroxine, and the mechanism responsible for the synthesis of cholesterol. <\/jats:p>","DOI":"10.1139\/o66-075","type":"journal-article","created":{"date-parts":[[2009,12,17]],"date-time":"2009-12-17T22:06:04Z","timestamp":1261087564000},"page":"625-633","source":"Crossref","is-referenced-by-count":0,"title":["EFFECTS OF PYRIDOXINE DEFICIENCY AND DIETARY CHOLESTEROL SUPPLEMENTATION IN THE CHICK ON PLASMA PROTEIN-BOUND IODINE, GLUTAMIC\u2013OXALACETIC TRANSAMINASE ACTIVITY, AND <sup>14<\/sup>C-ACETATE INCORPORATION INTO CHOLESTEROL"],"prefix":"10.1139","volume":"44","author":[{"given":"P. J.","family":"Lupien","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"p_1\/p_1_1","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1139\/o64-052","volume":"42","author":"LUPIEN B, B","year":"1964","journal-title":"Can. J. 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