{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T05:10:40Z","timestamp":1768626640550,"version":"3.49.0"},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"10","license":[{"start":{"date-parts":[[1978,10,1]],"date-time":"1978-10-01T00:00:00Z","timestamp":276048000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Biochem."],"published-print":{"date-parts":[[1978,10,1]]},"abstract":"<jats:p> Exchange transfusions in dogs were performed with a solution of either dextran or a covalent complex between dextran and human hemoglobin. Dogs transfused with dextran alone died when their hematocrit was lowered to 6\u201310%. Dogs transfused with the dextran\u2013hemoglobin complex, however, survived a reduction of their hematocrit to 2% or below. In the latter animals, the dextran\u2013hemoglobin complex disappeared from the circulation with an average half-life of 2.4 days. Correcting for oxidation of the hemoglobin moiety to methemoglobin, the half-life of functional unoxidized dextran\u2013hemoglobin in the circulation was 1.9 days. In compensation for the loss of dextran\u2013hemoglobin, vigorous erythropoiesis was observed at a rate of close to 5% hematocrit per day over the first 2 days following the exchange transfusion. As a result, the total hemoglobin concentration in blood was maintained at 5\u20136% during this period, and the animals went on to complete recovery in room air without the need for further transfusion with dextran\u2013hemoglobin. <\/jats:p>","DOI":"10.1139\/o78-153","type":"journal-article","created":{"date-parts":[[2009,12,21]],"date-time":"2009-12-21T14:53:57Z","timestamp":1261407237000},"page":"981-984","source":"Crossref","is-referenced-by-count":36,"title":["Blood replacement in dogs by dextran\u2013hemoglobin"],"prefix":"10.1139","volume":"56","author":[{"given":"Siu-Cheung","family":"Tam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Blumenstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Tze-Fei","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/o78-153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T22:51:14Z","timestamp":1578264674000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/o78-153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,10,1]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1978,10,1]]}},"alternative-id":["10.1139\/o78-153"],"URL":"https:\/\/doi.org\/10.1139\/o78-153","relation":{},"ISSN":["0008-4018"],"issn-type":[{"value":"0008-4018","type":"print"}],"subject":[],"published":{"date-parts":[[1978,10,1]]}}}